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Role of the glycolipid receptor in the digestive tract and bacterial glycolipid antigen in bacterial infection and symbiosis

Research Project

Project/Area Number 24570141
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Structural biochemistry
Research InstitutionKinki University

Principal Investigator

IWAMORI Masao  近畿大学, 理工学部, 教授 (90110022)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords共生細菌 / グリセロ糖脂質 / スフィンゴ糖脂質 / 自然抗体 / TLC-免疫染色 / 細菌受容体糖脂質 / GA1のフコシル化 / ABO血液型ヒト血清 / 糖脂質 / フコース転移酵素 / 消化管上皮 / 硫酸化糖脂質 / フコシル化糖脂質 / 免疫不全マウス / 共生乳酸菌 / 細菌受容体 / 免疫不全 / スルホ糖脂質
Outline of Final Research Achievements

Intestinal lactobacilli in immune-deficient scid mice were distinct from those in control mice, i.e. L. murinus (LM) for scid and L. johnsonii (LJ) for control, respectively, which were closely related with the loose and solid properties of the caecal and colonal contents of scid and control mice, respectively. LJ contained LacTH-DG and LacTetH-DG, both of which were modified LacDH-DG with Galα1-6 linkage, whereas, LM contained LacβTH-DG modified LacDH-DG with Glcβ1-6 linkage. Since natural antibodies toward LacTH-DG and LacTetH-DG were frequently detected in human sera, irrespective of ABO-blood groups, in the similar intensities as those toward blood groups- and species-specific glycolipids, immune system is involved in the establishment of symbiotic relationship with bacteria in the intestine. On the other hand, enhanced fucosylation of GA1 as a receptor for LJ occurred in the digestive tracts of scid mice, probably to interfere the formation of bacterial flora of LJ by LM.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (28 results)

All 2015 2014 2013 2012 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (16 results)

  • [Journal Article] Absence of lactobacilli containing glycolipids with the α-galactose epitope and the enhanced fucosylation of a receptor glycolipid GA1 in the digestive tracts of immune-deficient scid mice.2015

    • Author(s)
      Iwamori M, Tanaka K, Adachi S, Aoki D, Nomura T.
    • Journal Title

      J Biochem.

      Volume: 157

    • NAID

      40020522527

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Lewis y enhances CAM-DR in ovarian cancer cells by activating the FAK signaling pathway and upregulating Bcl-2/Bcl-XL expression.2015

    • Author(s)
      Yan LM, Wang CZ, Lin B, Liu JJ, Liu DW, Hou R, Wang YF, Gao LL, Zhang SL, Iwamori M.
    • Journal Title

      Biochimie.

      Volume: 113 Pages: 17-25

    • DOI

      10.1016/j.biochi.2015.01.013

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Expression of sulfatide and sulfated lactosylceramide among histological types of human ovarian carcinomas.2015

    • Author(s)
      Tanaka K, Mikami M, Aoki D, Kiguchi K, Ishiwata I, Iwamori M.
    • Journal Title

      Hum Cell

      Volume: 28 Issue: 1 Pages: 37-43

    • DOI

      10.1007/s13577-014-0100-4

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Enhanced expression of fucosyl GA1 in the digestive tract of immune-deficient scid, nude and IgR (-/-) mice.2013

    • Author(s)
      Masao Iwamori, et al.
    • Journal Title

      J. Biochem.

      Volume: 154(6) Issue: 6 Pages: 541-549

    • DOI

      10.1093/jb/mvt087

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Changes in bacterial glycolipids as an index of intestinal lactobacilli and epithelial glycolipids in the digestive tracts of mice after administration of penicillin and streptomycin.2013

    • Author(s)
      Masao Iwamori, et al.
    • Journal Title

      Glycoconj J.

      Volume: 30(9) Issue: 9 Pages: 889-897

    • DOI

      10.1007/s10719-013-9494-6

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Extracellular lipid metabolism influences the survival of2013

    • Author(s)
      Kuwata S, Ohkubo K, Kumamoto S, Yamaguchi N, Izuka N, Murota K, Tsujiuchi T,
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 439 Issue: 2 Pages: 280-284

    • DOI

      10.1016/j.bbrc.2013.08.041

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Altered phospholipid molecular species and glycolipid2013

    • Author(s)
      Miyazaki C, Saitoh M, Itoh M, Yamashita S, Miyagishi M, Takashima S, Moser AB,
    • Journal Title

      Neurosci Lett.

      Volume: 552 Pages: 71-75

    • DOI

      10.1016/j.neulet.2013.07.045

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bacterial species-characteristic profiles of molecular species, and the antigenicity of phospholipids and glycolipids in symbiotic Lactobacillus, Staphylococcus and Streptococcus species.2012

    • Author(s)
      Iwamori M, Nakasa M, Yamazaki K, Iwamori Y, Tanaka K, Aoki D, Adachi S, Nomura T.
    • Journal Title

      Glycoconjugate Journal

      Volume: 29 Pages: 199-209

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Enhanced Expression of Sulfatide, a Sulfated Glycolipid, in Well-Differentiated Endometrial Adenocarcinoma2012

    • Author(s)
      Sugiyama T, Miyazawa M, Mikami M, Goto Y, Nishijima Y, Ikeda M, Hirasawa T, Muramatsu T, Takekoshi S and Iwamori M
    • Journal Title

      International Journal of Gynecological Cancer

      Volume: 22 Issue: 7 Pages: 1192-1197

    • DOI

      10.1097/igc.0b013e31825f639f

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Possible involvement of glycolipids in anticancer drug resistance of human ovarian serous carcinoma-derived cells2012

    • Author(s)
      Tanaka K, Takada H, Isonishi S, Aoki D, Mikami M, Kiguchi K and Iwamori M
    • Journal Title

      J.Biochem

      Volume: 152 Issue: 6 Pages: 587-594

    • DOI

      10.1093/jb/mvs112

    • NAID

      10031166177

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lewis y Regulate Cell Cycle Related Factors in Ovarian Carcinoma Cell RMG-I in Vitro via ERK and Akt Signaling Pathways.2012

    • Author(s)
      Liu D, Liu J, Lin B, Liu S, Hou R, Hao Y, Liu Q, Zhang S, Iwamori M.
    • Journal Title

      Int J Mol Sci.

      Volume: 13 Issue: 1 Pages: 828-839

    • DOI

      10.3390/ijms13010828

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lewis Y regulates signaling molecules of the transforming growth factor β pathway in ovarian carcinoma-derived RMG-I cells.2012

    • Author(s)
      Li FF, Liu JJ, Liu DW, Lin B, Hao YY, Cong JP, Zhu LC, Gao S, Zhang SL, Iwamori M.
    • Journal Title

      Int J Oncol.

      Volume: 40 Issue: 4 Pages: 1196-1202

    • DOI

      10.3892/ijo.2011.1296

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 免疫不全scidマウス消化管にはα-ガラクトースエピトープ含有糖脂質を持つ乳酸菌は棲息していない2014

    • Author(s)
      岩森正男、岩森由里子、足立成基、野村大成、田中京子、青木大輔
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都国際会館(京都府京都市)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 多価不飽和脂肪酸は活性酸素産生とMAPキナーゼ経路活性化を介して卵巣がん細胞死を引き起こす2014

    • Author(s)
      福嶋伸之、田中亜衣子、辻内俊文、岩森正男
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都国際会館(京都府京都市)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒト子宮頸癌細胞におけるGM2糖鎖を持つガングリオシドの発現2014

    • Author(s)
      田中京子、宮澤昌樹、三上幹男、青木大輔、木口一成、岩森正男
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 子宮頸部腺癌におけるSulfatideの役割と機能2014

    • Author(s)
      宮澤 昌樹、宮澤 麻里子、杉山 太朗、松井 成明、藤井 幸子、池田 仁惠、信田 政子、平澤 猛、梶原 博、村松 俊成、岩森 正男、三上 幹男
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 乳酸菌の腸内共生と免疫の役割2014

    • Author(s)
      岩森正男、足立成基、野村大成, 田中京子、青木大輔
    • Organizer
      第56回日本脂質生化学会
    • Place of Presentation
      近畿大学(大阪府東大阪市)
    • Year and Date
      2014-06-06 – 2014-06-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] ペルオキシソーム形成異常症におけるリン脂質・糖脂質分子種変化2014

    • Author(s)
      宮崎セリーヌ、齋藤真木子、伊東雅之、山下純正、宮岸真、高嶋幸男、Ann B Moser、岩森正男、水口雅
    • Organizer
      第56回日本脂質生化学会
    • Place of Presentation
      近畿大学(大阪府東大阪市)
    • Year and Date
      2014-06-06 – 2014-06-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 各種乳酸菌の糖脂質の構造的特徴と抗原性2014

    • Author(s)
      南領将、谷河みなみ、枡田尚也、伊東玲芳、田中京子、青木大輔、岩森正男
    • Organizer
      第61回日本生化学会近畿支部例会
    • Place of Presentation
      京都産業大学(京都府京都市)
    • Year and Date
      2014-05-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] マウス消化管乳酸菌の抗生物質投与下での生息状況―細菌糖脂質抗原を指標とした解析―2013

    • Author(s)
      岩森正男、岩森由里子、足立成基、野村大成
    • Organizer
      第55回日本脂質生化学会
    • Place of Presentation
      大観荘(宮城県松島)
    • Related Report
      2013 Research-status Report
  • [Presentation] ペニシリン、ストレプトマイシン投与によるマウス消化管上皮および内容物の糖脂質変化2013

    • Author(s)
      岩森正男、岩森由里子、足立成基、野村大成
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2013 Research-status Report
  • [Presentation] Possible involvement of glycolipids in anticancer drug resistance of human ovarian serous carcinoma-derived cells.2013

    • Author(s)
      Kyoko Tanaka, Seiji Isonishi, Daisuke Aoki, Mikio Mikami, Kazushige Kiguchi, Masao Iwamori
    • Organizer
      104th Annual Meeting on American Association for Cancer Research
    • Place of Presentation
      Walter E. Washington Convention Center (Washington D.C., USA)
    • Related Report
      2013 Research-status Report
  • [Presentation] 脂肪酸による卵巣がん細胞HNOAの細胞死抑制機構2013

    • Author(s)
      福嶋伸之、辻内俊文、岩森正男
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2013 Research-status Report
  • [Presentation] 糖脂質硫酸基転移酵素遺伝子の導入によるヒト子宮内膜癌細胞の形質変化2013

    • Author(s)
      田中京子、石渡勇、久布白兼行、青木大輔、三上幹男、木口一成、岩森正男
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2013 Research-status Report
  • [Presentation] 免疫不全マウス消化管におけるフコシルGA1の発現増加2012

    • Author(s)
      岩森正男、岩森由里子、足立成基、野村大成
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] 消化管、皮膚および口腔共生細菌脂質の特異的分子種構成と糖脂質の抗原性2012

    • Author(s)
      岩森正男、岩森由里子、田中京子、青木大輔、足立成基、野村大成
    • Organizer
      第54回日本脂質生化学会
    • Place of Presentation
      九州大学医学部
    • Related Report
      2012 Research-status Report
  • [Presentation] ヒト漿液性卵巣癌細胞の抗がん剤耐性と糖脂質の関与2012

    • Author(s)
      田中京子、磯西成治、青木大輔、三上幹男、木口一成、岩森正男
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ホテルロイトン札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 共生細菌Lactobacillus, Staphylococcus, Streptococcus属脂質の細菌属特異的分子種構成と糖脂質の抗原性

    • Author(s)
      中佐昌紀,山崎健太郎,岩森由里子,岩森正男
    • Organizer
      第59回日本生化学会近畿支部例会
    • Place of Presentation
      京都大学宇治キャンパス
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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