| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
We previously found that activation of EGF receptor signaling triggers translocation of the membrane-bound NEU3 sialidase from cytoplasm to cell membrane, which had not been reported for other glycoenzymes. To gain an insight into the molecular mechanism underlying NEU3 intracellular trafficking, we attempted to identify proteins which can interact with NEU3 in cells. We identified evectin, CAMK1G, MAP1A, and ITM2C as potent candidates for NEU3-binding proteins and got structural information about the interaction. These results could provide an important clue for understanding how NEU3 modulates signal transductions and subsequently affects on pathological conditions such as cancer or diabetes.
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