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The role of lipid rafts in recognition of extracellular matrix remodeling by cancer cells

Research Project

Project/Area Number 24570154
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Functional biochemistry
Research InstitutionOsaka University

Principal Investigator

MURAI TOSHIYUKI  大阪大学, 医学系研究科, 助教 (20311756)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords細胞・組織 / シグナル伝達 / 分子認識
Outline of Final Research Achievements

Hyaluronan is a major component of the extracellular matrix and plays pivotal roles in inflammation and cancer. Lipid rafts are cholesterol- and glycosphingolipid-enriched membrane microdomains that may regulate membrane receptors while serving as platforms for transmembrane signaling at the cell surface. In this study, we demonstrated that lipid rafts regulate the interactions between hyaluronan and its receptor CD44, and control the cell adhesion and migration. Our results propose a possible molecular mechanism underlying cell migration. The regulation and manipulation of hyaluronan-CD44 interactions through lipid rafts have potential applications for the prevention of inflammatory disorders and cancer.

Report

(4 results)
  • 2015 Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (7 results)

All 2015 2014 2013 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] Cholesterol lowering: role in cancer prevention and treatment.2015

    • Author(s)
      Murai, T.
    • Journal Title

      Biol. Chem.

      Volume: 396 Issue: 1 Pages: 1-11

    • DOI

      10.1515/hsz-2014-0194

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 細胞表層のドメイン構造と細胞運動2014

    • Author(s)
      村井稔幸
    • Journal Title

      顕微鏡

      Volume: 49 Pages: 10-13

    • NAID

      130007701780

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Membrane cholesterol modulates the hyaluronan-binding ability of CD44 in T lymphocytes and controls rolling under shear flow.2013

    • Author(s)
      Murai T, Sato C, Sato M, Nishiyama H, Suga M, Mio K, Kawashima H.
    • Journal Title

      Journal of Cell Science

      Volume: 126 Pages: 3284-3294

    • DOI

      10.1242/jcs.120014

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ultrastructural analysis of nanogold-labeled cell surface microvilli in liquid by atmospheric scanning electron microscopy and their relevance in cell adhesion2013

    • Author(s)
      Murai, T. et al.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 14 Issue: 10 Pages: 20809-20819

    • DOI

      10.3390/ijms141020809

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 大気圧走査電子顕微鏡(ASEM)による水中免疫電顕法:タンパク質複合体のダイナミックな離合集散と細胞内移動2013

    • Author(s)
      海老原達彦 他5名
    • Journal Title

      顕微鏡

      Volume: 48 Pages: 107-112

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 膜脂質ドメインと細胞ダイナミクス2013

    • Author(s)
      村井稔幸
    • Journal Title

      生物工学会誌

      Volume: 91 Pages: 21-21

    • NAID

      110009580284

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 大気圧走査電子顕微鏡を用いた様々な応用例

    • Author(s)
      村井稔幸 他6名
    • Organizer
      日本臨床分子形態学会・学術集会
    • Place of Presentation
      高知市文化プラザ(高知県)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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