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Analyses of nucleotide excision repair factors in the regulation of gene expression

Research Project

Project/Area Number 24570156
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Functional biochemistry
Research InstitutionOsaka University

Principal Investigator

NARITA Takashi  大阪大学, 生命機能研究科, 特任助教 (50437399)

Research Collaborator SAIJO Masafumi  大阪大学, 大学院生命機能研究科, 准教授 (90221986)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsDNA修復 / 転写 / 遺伝情報発現 / 色素性乾皮症 / 遺伝子発現制御 / 転写伸長 / ヌクレオチド除去修復 / 遺伝子発現
Outline of Final Research Achievements

The results showed that XPG-TFIIH complex interacts with transcription elongation complex. Transcription assays and chromatin immunoprecipitation experiments revealed that XPG-TFIIH complex is involved in regulating a wide range of gene expression. Furthermore, the functions of XPG-TFIIH complex in transcription have relevance to the CS features in XP-G/CS patients. These results will be helpful to understand the relationship between the mutations in XP-G patients and their clinical features at a molecular level.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report

Research Products

(2 results)

All 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes2014

    • Author(s)
      J. Yamamoto, Y. Hagiwara, K. Chiba, T. Isobe, T. Narita, H. Handa, Y. Yamaguchi
    • Journal Title

      Nature Communications

      Volume: 5 Pages: 4263-4263

    • DOI

      10.1038/ncomms5263

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] XPG-TFIIH複合体による転写伸長反応の制御機構の解析2014

    • Author(s)
      成田央・成田圭子・竹立新人・田中亀代次
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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