Innovative approach to control virus-infectious diseases by manipulation of glycan function
| Project/Area Number |
24570168
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | The University of Aizu Junior College Division (2013-2014)
University of Shizuoka (2012) |
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Principal Investigator |
HIDARI Kazuya 会津大学短期大学部, その他部局等, 教授 (20260226)
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| Co-Investigator(Renkei-kenkyūsha) |
森田 公一 長崎大学, 熱帯医学研究所, 教授 (40182240)
池田 潔 広島国際大学, 薬学部, 教授 (40168125)
常盤 広明 立教大学, 理学部, 教授 (10221433)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 糖鎖生物学 / ウイルス / 感染症 |
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| Outline of Final Research Achievements |
Host factors are essential for virus maturation in cells and pathogenesis caused by dengue (DEN) and Japanese encephalitis (JE) virus infection. We executed the current research subject, the elucidation of molecular mechanisms on virus proliferation and pathogenic progression by structural optimization of functional glycans involved in these virus infection.
In summary, we characterized carbohydrate substrates which contribute to virus invasion and maturation inside host cells, found the anti-viral activity in an edible mushroom extract, generated a novel anti-viral agent, and identified putative a carbohydrate factor for virus tropism and pathogenic progression.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] Measurement of aberrant glycosylation of prostate specific antigen can improve specificity in early detection of prostate cancer.2014
Author(s)
Yoneyama T, Ohyama C, Hatakeyama S, Narita S, Habuchi T, Koie T, Mori K, Hidari KI, Yamaguchi M, Suzuki T, Tobisawa Y
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Journal Title
Biochem Biophys Res Commun.
Volume: 448
Issue: 4
Pages: 390-396
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Improvement of Depression-Like Behavior and Memory Impairment with the Ethanol Extract of Pleurotus eryngii in Ovariectomized Rats.2013
Author(s)
Akira Minami, Hiroshi Matsushita, Yuuki Horii, Daisuke Ieno, Yukino Matsuda, Masakazu Saito, Hiroaki Kanazawa, Yuriko Ohyama, Akihiko Wakatsuki, Atsushi Takeda, Kazuya I.P.J. Hidari, Vikineswary Sabaratnam, Takashi Suzuki
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Journal Title
Biol. Pharm. Bull.
Volume: 36
Pages: 1990-1995
Related Report
Peer Reviewed
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[Journal Article] Design and synthesis of a novel ganglioside ligand for influenza A viruses2012
Author(s)
Nohara, T., Imamura, A., Yamaguchi, M., Hidari, K.I.P.J., Suzuki, T., Komori, T., Ando, H., Ishida, H. and Kiso, M.
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Journal Title
Molecules
Volume: 17
Issue: 8
Pages: 9590-9620
DOI
Related Report
Peer Reviewed
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[Journal Article] No evidence of horizontal infection in horses kept in close contact with dogs experimentally infected with canine influenza A virus (H3N8).2012
Author(s)
T. Yamanaka, M. Nemoto, H. Bannai, K. Tsujimura, T. Kondo, T. Matsumura, M. Muranaka, T. Ueno, Y. Kinoshita, H. Niwa, K.I.P.J. Hidari, T. Suzuki
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Journal Title
Acta Vet. Scand.
Volume: 54
Issue: 1
Pages: 25-25
DOI
Related Report
Peer Reviewed
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