| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Integrin α5β1-mediated cell adhesion regulates a multitude of cellular responses, including proliferation, survival and cross-talk between different cellular signaling pathways. Here we analyzed whether N-glycosylation on integrin involved cell proliferation and supramolecular assembly. We identified specific N-glycosylation sites regulating cell prolification and supramolecular assembly. Furthermore, we found that Golgi phosphoprotein 3 (GOLPH3) regulates an efficient synthesis of N-glycosylation and cell migration.
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