Functional analysis of N-glycan on integrin alpha5beta1 for supramolecular assembly and cell proliferation
Project/Area Number |
24570169
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Functional biochemistry
|
Research Institution | Tohoku Pharmaceutical University |
Principal Investigator |
ISAJI Tomoya 東北薬科大学, 薬学部, 助教 (80433514)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | インテグリン / 接着 / 細胞増殖 / 超分子複合体 / 糖鎖 / 複合体形成 |
Outline of Final Research Achievements |
Integrin α5β1-mediated cell adhesion regulates a multitude of cellular responses, including proliferation, survival and cross-talk between different cellular signaling pathways. Here we analyzed whether N-glycosylation on integrin involved cell proliferation and supramolecular assembly. We identified specific N-glycosylation sites regulating cell prolification and supramolecular assembly. Furthermore, we found that Golgi phosphoprotein 3 (GOLPH3) regulates an efficient synthesis of N-glycosylation and cell migration.
|
Report
(4 results)
Research Products
(11 results)
-
[Journal Article] An Oncogenic Protein Golgi Phosphoprotein 3 up-regulates Cell Migration via Sialylation.2014
Author(s)
Isaji T, Im S, Gu W, Wang Y, Hang Q, Lu J, Fukuda T, Hashii N, Takakura D, Kawasaki N, Miyoshi H, Chin L, Gu J
-
Journal Title
J.Biol. Chem.
Volume: 289
Issue: 30
Pages: 20694-20705
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
[Journal Article] MicroRNA 130b suppresses migration and invasion of colorectal cancer cells through downregulation of integrin.2014
Author(s)
Zhao, Y., Miao, G., Li, Y., Isaji, T., Gu, J., Li, J., Qi, R.
-
Journal Title
PLoS One
Volume: 9
Issue: 2
Pages: e87938-e87938
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] α1,6-Fucosylation regulates neurite formation via the activin/phospho-Smad2 pathway in PC12 cells: the implicated dual effects of Fut8 for TGF-β/activin-mediated signaling.2013
Author(s)
Gu, W., Fukuda, T., Isaji, T., Hashimoto, H., Wang., Y and Gu, J.
-
Journal Title
FASEB J
Volume: 27
Issue: 10
Pages: 3947-3958
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-