| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Bach2 plays an important role in the transcriptional process. Bach2 includes long intrinsically disordered regions. We prepared the region of 331-520 to investigate its biophysical properties. Spectroscopic measurements revealed that Bach2(331-520) is intrinsically disordered region, in which heme binds. SAXS and dynamic light scattering mesurements indicated that heme binding form of Bach2(331-520) is unstabler than the non heme binding form and the structure will be more compact. Our results showed the first example of the heme binding protein which is (1) intrinsically disordered protein/region, (2) indicates structural change by heme binding.
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