Development and analyses of integrated networks for cellular function predictions
Project/Area Number |
24570176
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Biophysics
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Research Institution | Tohoku University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 遺伝子共発現 / 蛋白質間相互作用 / 統合ネットワーク / 種間比較 / クラスター解析 / タンパク質間相互作用 / 相互作用ネットワーク / 遺伝子共発現ネットワーク / ネットワーククラスタリング |
Outline of Final Research Achievements |
We have more than several thousands of whole genome sequences of many divergent species, but more than half of the genes on the genomes are still uncharacterized. It is almost impossible to determine all functions of all genes by experimental procedure, and thus some computational approaches to infer some possible functions of the uncharacterized genes. In this study, we have constructed integrated networks by using RNA-seq based co-expression networks and high throughput protein-protein interaction data, and developed a method to compare the integrated networks among the species. We also developed a new clustering method and applied it to infer the cellular function of uncharacterized genes.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Okamura Y, Aoki Y, Obayashi T, Tadaka S, Ito S1, Narise T, Kinoshita K.2015
Author(s)
Okamura Y, Aoki Y, Obayashi T, Tadaka S, Ito S1, Narise T, Kinoshita K.
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Journal Title
Nucleic Acid Res
Volume: 43
Issue: D1
Pages: D82-D86
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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