| Project/Area Number |
24570184
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biophysics
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| Research Institution | Osaka University |
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Principal Investigator |
リャン スートウ 大阪大学, 免疫学フロンティア研究センター, 特任助教 (30598157)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Discontinued (Fiscal Year 2014)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | タンパク質ループモデリング / タンパク質の設計 / タンパク質力場 / 蛋白質 - 蛋白質相互作用 / 蛋白質ー蛋白質相互作用 |
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| Outline of Annual Research Achievements |
In 2014 fiscal year, we applied the OSCAR force fields for protein decoy selection. Among decoys refined with the same procedure, the OSCAR-force fields are good in selecting the one with a low RMSD (root mean square deviation) to the native structure. The high performance of OSCAR force fields in protein decoy selection boost our confidence to apply the force fields for protein design.
So far, although there has been none in FY2014, we published three papers supported by this grant achieving our minimum goal in publication. However, we did not finish all of research work as planned. Especially, we did not finish and computationally test the protein interface design program based on the OSCAR force fields because my work contract with Osaka University ended in Oct 2014 and the Kakenhi was planned for the time period between April 2012 and March 2015. I left Japan at the end of October 2014 and turned in all of remaining fund.
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