Studies of molecular mechanisms regulating meiotic chromosome dynamics
| Project/Area Number |
24570194
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | Shizuoka University |
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Principal Investigator |
YAMAMOTO Ayumu 静岡大学, 理学(系)研究科(研究院), 教授 (70359082)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 減数分裂 / 相同染色体 / 姉妹染色分体 / キアズマ / 微小管 / 動原体 / テロメア / 細胞生物学 / 分子生物学 / セントロメア / 染色体分配 |
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| Outline of Final Research Achievements |
Meiosis is a type of cell division, which generates haploid gametes. During meiosis, homologous chromosomes become connected by recombination products called chiasmata. In this study, we examined roles of chiasmata in homologous chromosome segregation and the mechanism of telomere clustering, which is required for chiasma formation, in fission yeast. We found that chiasmata play critical roles in correcting erroneous attachments of chromosomes to the spindle, and that telomere clustering depends on microtubules emanating from the telomeres and microtubule motors.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Microtubule -organizing center formation at telomeres induces meiotic telomere clustering2013
Author(s)
Yoshida M, Katsuyama S, Tateho K, Nakamura H, Miyoshi J, Ohba T, Matsuhara H, Miki F, Okazaki K, Haraguchi T, Niwa O, Hiraoka Y, Yamamoto A
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Journal Title
J. Cell Biol
Volume: 200
Issue: 4
Pages: 385-395
DOI
Related Report
Peer Reviewed
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[Presentation] Meiotic telomere clustering depends on the telocentrosome, a novel microtubule-organizing center formed at the telomere.2013
Author(s)
Masashi Yoshida, Satoshi Katsuyama, Kazuki Tateho, Hiroto Nakamura, Junpei Miyoshi, Tatsunori Ohba, Hirotada Matsuhara, Futaba Miki, Koei Okazaki, Tokuko Haraguchi, Osami Niwa, Yassushi Hiraoka, Ayumu Yamamoto
Organizer
7th International Fission Yeast Meeting
Place of Presentation
University of London (London, UK)
Related Report
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