| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Chromosome condensation is a basic cellular process that ensures the faithful segregation of chromosomes during cell division. Recent studies demonstrated that chromosome condensation is mainly achieved by condensin, a multi0subunit protein complex widely conserved from yeast to human. In this study, I showed that condensin play a role in chromatin interactions and this interaction lead to create chromatin folding. It is thought that condensin-dependent chromatin folding is one of the basic molecular processes for chromosome condensation during M-phase. In addition, it is demonstrated that condensin regulate chromosome folding in interphase too.
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