Effects of Varp on the activation of melanocytes
| Project/Area Number |
24570206
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 色素細胞 / メラニン / 突起形成 / 低分子量Gタンパク質 / Rab / メラノサイト / チロシナーゼ / Tyrp1 / フォルスコリン |
|---|
| Outline of Final Research Achievements |
Melanin helps protect human beings from harmful ultra-violet exposure, but the excess production of melanin causes skin stains and freckles, therefore regulating the amount of melanin in skin is essential for maintaining quality of life. Melanocytes are known as melanin-producing cells and activated upon UV stimulation to transfer melanosomes that contain melanin toward the neighboring keratinocytes and hair matrix cells. This research demonstrated that one of the guanine nucleotide exchange factors, named Varp, activates Rab21 to elongate melanocytic dendrites, which facilitates the transfer of melanin from melanocytes to neighboring keratinocytes.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Rab5 is a novel regulator of mast cell secretory granules: impact on size, cargo, and exocytosis.2014
Author(s)
Azouz, N.P., Zur, N., Efergan, A., Ohbayashi, N., Fukuda, M., Amihai, D., Hammel, I., Rothenberg, M.E., and Sagi-Eisenberg, R.
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Journal Title
J. Immunol.
Volume: 192
Issue: 9
Pages: 4043-4053
DOI
Related Report
Peer Reviewed
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[Journal Article] Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma membrane recycling.2014
Author(s)
McGough, I. J., Steinberg, F., Gallon, M., Yatsu, A., Ohbayashi, N., Heesom, K., Fukuda, M. and Cullen, P. J.
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Journal Title
J. Cell Sci.
Volume: 127
Pages: 4940-4953
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The GTPase Rab37 Participates in the Control of Insulin Exocytosis.2013
Author(s)
Ljubicic, S., Bezzi, P., Brajkovic, S., Nesca, V., Guay, C., Ohbayashi, N., Fukuda, M., Abderrhamani, A., and Regazzi, R.
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Journal Title
PLoS One
Volume: 8
Issue: 6
Pages: e68255-e68255
DOI
Related Report
Peer Reviewed
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