Study on the cytokinetic signal in closed-mitosis organisms and control of cell-division pattern in dimorphism
Project/Area Number |
24570207
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cell biology
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Research Institution | University of Tsukuba |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | アクチン / ミオシン / 細胞分裂 / 分裂酵母 / 細胞質分裂 / 細胞骨格 / 酵母 / シグナル伝達 / 収縮環 / 形態形成 / 細胞内輸送 / 細胞内極性 |
Outline of Final Research Achievements |
In animal cells, the contractile ring (CR) is formed beneath the plasma membrane in a foredivision site after nuclear division, and the CR constricts to pinch the cell into two. However, cytokinetic signal has not been uncovered in the closed mitosis organisms including yeasts and protozoa. The fission yeast Schizosaccharomyces pombe is an ideal organism for studying the molecular mechanism of cytokinesis. In this organism, CR is found in a dividing site as well as in animal cells, but its assembly is completed prior to the onset of nuclear division. In this project, we investigated a role of proteins responsible for the cytokinetic signal in S. pombe and its related species. As a result, we found that the major regulatory protein for CR assembly in S. pombe plays only an auxiliary role in the other species. Thus, fission yeasts probably have multiple cytokinetic-signalling systems, and the dependencies on each system may be different between the species.
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Report
(4 results)
Research Products
(13 results)
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[Presentation] 酵母の細胞の形づくり2014
Author(s)
中野賢太郎
Organizer
酵母細胞研究会定例会
Place of Presentation
東京都文京区、東京大学中嶋董一郎記念ホール
Year and Date
2014-12-12
Related Report
Invited
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