| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The 26S proteasome is a eukaryotic protease complex conserved from yeast to human. In eukaryotes, the 26S proteasome is essential for growth, but where this essentiality comes from remains unknown. To address this issue, I examined two peptidase activities, which reside only in eukaryotic proteasomes, the functional relationship between the 26S proteasome and mitochondria, which are the essential eukaryotic organelles, and some proteasome subunits, whose functions have not been clarified yet.
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