Why is the 26S proteasome essential for eukaryotic cell viability?
| Project/Area Number |
24570208
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YASHIRODA Hideki 東京大学, 薬学研究科(研究院), 准教授 (20311425)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | プロテアソーム / タンパク質分解 / 出芽酵母 / ミトコンドリア |
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| Outline of Final Research Achievements |
The 26S proteasome is a eukaryotic protease complex conserved from yeast to human. In eukaryotes, the 26S proteasome is essential for growth, but where this essentiality comes from remains unknown. To address this issue, I examined two peptidase activities, which reside only in eukaryotic proteasomes, the functional relationship between the 26S proteasome and mitochondria, which are the essential eukaryotic organelles, and some proteasome subunits, whose functions have not been clarified yet.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Pba3-Pba4 heterodimer acts as a molecular matchmaker in proteasome α-ring formation2014
Author(s)
Takagi, K., Saeki, Y., Yashiroda, H., Yagi, H., Kaiho, A., Murata, S., Yamane, T., Tanaka, K., Mizushima, T. and Kato, K.
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 450
Issue: 2
Pages: 1110-1114
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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