| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
We have identified segmentation genes that are upregulated in embryos of Drosophila G9a (dG9a) mutant. Since temporal and spatial expression pattern of these segmentation genes are not changed in dG9a mutant embryos in compared with the wild type, delay in embryogenesis of the dG9a mutant is likely caused by the changes in expression level of their mRNAs. Genome wide genetic screen by using the rough eye phenotype induced by eye disc specific dG9a-overexpression identified a set of genes involved in the EGFR signaling pathway and autophagy. In consistent with these observations, the dG9a mutant showed high sensitivity to starvation stress that induce autophagy. These findings provide important clues to clarify epigenetic regulation of autophagy.
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