Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Outline of Final Research Achievements |
Formation of cell polarity plays fundamental roles in cell migration, cell differentiation, and carcinogenesis etc. The mammalian Golgi appratus has important function in the formation of cell polarity. In this study, we showed that histone methylation enzyme is required for proper Golgi structure via LINC (linker of nucleoskeleton and cytoskeleton) complex, a nuclear envelope protein complex consisting mainly of the SUN and nesprin protein families. In addition, we demonstrated global loss of a nuclear lamina component, lamin A/C and LINC complex components SUN1, SUN2, and nesprin-2 in breast cancer.
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