The chromatin signaling regulates the formation of cell polarity.
Project/Area Number |
24570213
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cell biology
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Research Institution | Osaka University |
Principal Investigator |
HIEDA Miki 大阪大学, 医学(系)研究科(研究院), 助教 (00380254)
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Co-Investigator(Renkei-kenkyūsha) |
KURONO Sadamu (20271554)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | 核膜 / 細胞極性 / 乳癌 / LINC complex / 癌転移 / SUN1 / nesprin / SUN / ヒストンメチル化 / ヒストン / 細胞運動 / 乳がん / ヒストン修飾 / 癌細胞 |
Outline of Final Research Achievements |
Formation of cell polarity plays fundamental roles in cell migration, cell differentiation, and carcinogenesis etc. The mammalian Golgi appratus has important function in the formation of cell polarity. In this study, we showed that histone methylation enzyme is required for proper Golgi structure via LINC (linker of nucleoskeleton and cytoskeleton) complex, a nuclear envelope protein complex consisting mainly of the SUN and nesprin protein families. In addition, we demonstrated global loss of a nuclear lamina component, lamin A/C and LINC complex components SUN1, SUN2, and nesprin-2 in breast cancer.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] SUV420H2 suppresses breast cancer cell invasion through down regulation of the SH2 domain-containing focal adhesion protein tensin-3.2015
Author(s)
Shinchi, Y., Hieda, M.*, Nishioka, Y., Matsumoto, A., Yokoyama, Y., Kimura, H., Matsuura, S., Matsuura, N.
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Journal Title
Experimental Cell Research,
Volume: in press
Issue: 1
Pages: 90-99
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Loss of histone H4K20 trimethylation predicts poor prognosis in breast cancer and is associated with invasive activity.2014
Author(s)
Yokoyama Y, Matsumoto A, Hieda M*, Shinchi Y, Ogihara E, Hamada M, Nishioka Y, Kimura H, Yoshidome K, Tsujimoto M, Matsuura N.
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Journal Title
Breast Cancer Res.
Volume: 16
Issue: 3
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Cancer associated up-regulation of H3K9 methylation promotes cell motility in vitro and drives tumor formation in vivo.2013
Author(s)
Yokoyama, Y., Hieda, M., Nishioka, Y., Matsumoto, A., Higashi, S., Kimura, H., Yamamoto, H., Mori, M., Matsuura, S., and Matsuura, N.
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Journal Title
Cancer Science
Volume: 104
Issue: 7
Pages: 889-895
DOI
Related Report
Peer Reviewed
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[Journal Article] The cytoplasmic tail of Heparin-binding EGF like growth factor regulates bidirectional intracellular trafficking between the plasma membrane and ER.2012
Author(s)
Hieda, M., Koizumi, M., Higashi, C., Tachibana, T., Taguchi, T., and Higashiyama, S.
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Journal Title
FEBS Open Bio.
Volume: 4
Pages: 721-726
Related Report
Peer Reviewed
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[Presentation] H3 lysine 9 methylation promotes cell motility in vitro and drives tumor formation in vivo.2013
Author(s)
Yokoyama, Y., Hieda, M., Higashi, S., Nishioka, Y., Matsumoto, A., Kimura, H., Matsuura, S., Matsuura N.,
Organizer
Keystone Symposia, Epigenetic Marks and Cancer Drugs (C8)
Place of Presentation
Santa Fe, NM, USA
Related Report
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[Presentation] H3 lysine 9 methylation promotes cell motility in vitro and drives tumor formation in vivo; a possible explanation for the cancer-associated.2012
Author(s)
Hieda, M., Nishioka, Y., Yokoyama, Y., Matsuura, N., Matsuura, S.,
Organizer
Annual Meeting for the American Society for Cell Biology
Place of Presentation
San Francisco, CA, USA
Related Report
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[Presentation] Histone H3 lysine 9 methylation promotes cell motility in vitro and drives tumor formation in vivo2012
Author(s)
Hieda, M., Yokoyama, Y., Nishioka, Y., Kimura, H., Matsuura, S., Matsuura, S.
Organizer
Cold Spring Harbor Laboratory meeting, Epigenetics & Chromatin
Place of Presentation
Cold Spring Harbor, NY, USA
Related Report
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