Function and dynamics of dynamin family in cytokinesis
Project/Area Number |
24570218
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cell biology
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Research Institution | Yamaguchi University |
Principal Investigator |
YUMURA shigehiko 山口大学, 医学(系)研究科(研究院), 教授 (70183986)
|
Co-Investigator(Renkei-kenkyūsha) |
UYEDA Taro 産業総合研究所, バイオメディカル部門, 総括研究主幹 (90356551)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | ダイナミン / 細胞質分裂 / アクチン / ミオシン / 細胞性粘菌 |
Outline of Final Research Achievements |
Dynamin is an important protein to cut the vesicles from the cell membrane during endocytosis. Recently, dynamin has shown to play an important role on cytokinesis, which is a final stage of cell division. Inhibitors against dynamin, which can be used for targeting cytokinesis of cancer cells, are new potent and attractive anti-cancer reagents. This study clarified the function and dynamics of dynamin in cytokinesis of cellular slime mold cells, a model organism for cytokinesis. Dynamin null cells showed severe defects in cytokinesis, resulting in their multinucleation. Actin and myosin II could not recruit at the cleavage furrow properly. GFP-tagged dynamins accumulated to the cleavage furrow. We found that dynamins contribute to stabilization of actin in the contractile ring. Together, we proposed a new model for the role of dynamin in cytokinesis.
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Report
(4 results)
Research Products
(22 results)
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[Presentation] Bleb形成の制御機構2014
Author(s)
杉山達郎,祐村恵彦
Organizer
日本細胞生物学会
Place of Presentation
奈良市 奈良県新公会堂
Year and Date
2014-06-11 – 2014-06-13
Related Report
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