Regulation of the expression and the function of glucose transporters in response to the enviromental glucose concentrations.
| Project/Area Number |
24570221
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Kurume University |
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Principal Investigator |
SAITOH Shigeaki 久留米大学, 分子生命科学研究所, 教授 (30352123)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | グルコース / 輸送体 / シグナル伝達 / 分裂酵母 / CaMKK / TORキナーゼ / 糖代謝 / 転写制御 |
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| Outline of Final Research Achievements |
To drive various energy-consuming cellular processes, eukaryote cells are required to efficiently incorporate glucose, which is the fundamental source of energy. Glucose is incorporated into the cell through glucose transporters, which locates on the cell membrane. In this study, we utilize fission yeast as a model, and analyze regulations of the expression and the function of glucose/hexose transporters. Among the eight transporters found in the fission yeast genome, the Ght5 transporter is found to be essential for cell to utilize low glucose concentrations equivalent to that of human blood. Furthermore, we find that the expression and the localization on the cell membrane of Ght5 are regulated through the CaMKK and the TORC2 signaling pathways, respectively, which are evolutionarily conserved from yeasts to man.
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Report
(4 results)
Research Products
(16 results)
