| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Chemotaxis is directional motility along chemical gradients and observed in many biological situations, such as neutrophil migration to the infected site. Chemotactic cells have a typical polarized morphology with the distinct front and back, which is required for efficient motility. In this study, we found that the small GTPase-mediated TorC2-PDK-PKB (TPP) module is activated independently of external signals, known as self-organization ability important for cellular motility in chemotaxis. Also, its underling molecular dynamics on the plasma membrane were analyzed.
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