| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Outline of Final Research Achievements |
Because marsupial neonates are immature at birth, compared to those of placental mammals, they must travel into pouch and suckle on mother’s milk to complete the rest of development. Thus, forelimbs and jaw elements develop early in marsupials. To understand this temporal shift of the developmental program in marsupials, we analyzed cranial neural crest development in opossum embryos. We found that the Sox9 expression in opossum cranial neural crest starts earlier and persists longer in the neural crest-derived mesenchyme of jaw primordium, compared to those in mouse or chicken (see Wakamatsu et al., 2014). We also found that a marsupial-specific mutation in the neural crest enhancer of Sox9 gene, is responsible for the early expression of Sox9 in the cranial neural crest of opossum embryos.
|
