| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
The maturation and adaptation of the neural circuits in the brain is achieved via multiple steps involving axonal terminal branching, pruning of excess dendrites, and control of synaptogenesis. In this study, we utilized fruit flies (Drosophila melanogaster) to elucidate the molecular mechanisms that control the functional maturation and maximum tuning of neurocircuits in the brain, and analyzed fine branching patterns at the axonal termini and synapse formation. By the use of genetic screening, we have identified several key molecules that control these processes. Moreover, to extend this study to higher order brain functions, we have developed a novel technique that enables artificial induction of olfactory memory in living larvae. Our study has disclosed intriguing molecular genetic mechanisms of functional tuning of the neural circuits, and identified genes that are conserved in humans as risk factors for diverse mental disorders.
|
