| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
In Drosophila, five tarsal segments are created by changes in expression patterns of two transcription factors, Bar and Dac. Once initial state of Bar and Dac expression patterns are set, they induce the region-specific expression of Ds and Fj, which regulates Hippo signaling and cell proliferation. Then, cell proliferation locally induced by the region-specific expression of Ds and Fj in turn induces the timely expression of other transcription factors, such as Nub, Rn and Ap, which regulate change in Bar and Dac expression patterns. Our results indicate that developmental field are newly formed by the integration of regulation on gene expression and on local cell proliferation.
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