Integration of regulation of region-specific transcription factors and local cell proliferation in the formation of new developmental fields.
Project/Area Number |
24570230
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Developmental biology
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Research Institution | The University of Tokyo |
Principal Investigator |
Kojima Tetsuya 東京大学, 新領域創成科学研究科, 准教授 (80262153)
|
Project Period (FY) |
2012-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 昆虫 / 付属肢 / 発生分化 / 発現制御 / 細胞増殖制御 / Hippo pathway / 領域化 / Yorki / Four-jointed / Dachsous / ショウジョウバエ / 転写因子 / 細胞増殖 |
Outline of Final Research Achievements |
In Drosophila, five tarsal segments are created by changes in expression patterns of two transcription factors, Bar and Dac. Once initial state of Bar and Dac expression patterns are set, they induce the region-specific expression of Ds and Fj, which regulates Hippo signaling and cell proliferation. Then, cell proliferation locally induced by the region-specific expression of Ds and Fj in turn induces the timely expression of other transcription factors, such as Nub, Rn and Ap, which regulate change in Bar and Dac expression patterns. Our results indicate that developmental field are newly formed by the integration of regulation on gene expression and on local cell proliferation.
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Report
(5 results)
Research Products
(8 results)
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[Journal Article] Two adjacent cis-regulatory elements are required for ecdysone response of ecdysone receptor (EcR) B1 transcription.2012
Author(s)
Shirai,H., Kamimura,M., Yamaguchi,J., Imanishi,S., Kojima,T. and Fujiwara, H.
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Journal Title
PLOS One
Volume: 7(11) e:49348.
Issue: 11
Pages: e49348-e49348
DOI
Related Report
Peer Reviewed
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