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Analyses of controlling factors in elongation movements

Research Project

Project/Area Number 24570231
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Developmental biology
Research InstitutionThe University of Tokyo

Principal Investigator

NINOMIYA Hiromasa  東京大学, 総合文化研究科, 学術研究員 (40514237)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Shuji  広島大学, 理学系研究科, 特任准教授 (90447318)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords形態形成 / 細胞運動 / 組織分化 / 脊椎動物 / 形態形成運動 / 誘導 / 上皮
Outline of Final Research Achievements

I have studied about whether there are varieties in mechanisms of convergent extension regarding to cell directing role of tissue polarity. Xenopus neural, somitic and human dorsal mesoderm cell masses remained spherical shape in uniform differentiation states (= differentiation without tissue polarity), whereas the tissues elongated into direction of the polarity in biased differentiation states (= differentiation with tissue polarity). These results were consistent with previous experiments in Xenopus notochord tissue. Different combinations of signals induced the tissue polarity in different tissues. These results indicated that 1) "Tissue polarity is directing on convergent extension of the various vertebrate dorsal tissues" and 2) "Tissue polarity is induced by various combinations of signals".

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (17 results)

All 2015 2014 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (13 results)

  • [Journal Article] Improved efficiency of definitive endoderm induction from human induced pluripotent stem cells in feeder and serum-free culture system2015

    • Author(s)
      Ninomiya H, Mizuno K, Terada R, Miura T, Ohnuma K, Takahashi S, Asashima M, Michiue T
    • Journal Title

      In Vitro Cell Dev Biol Anim.

      Volume: 51 Issue: 1 Pages: 1

    • DOI

      10.1007/s11626-014-9801-y

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Complete mitochondrial genome of “xenopus tropicalis” Asashima line (Anura: Pipidae), a possible undescribed species2015

    • Author(s)
      Haramoto Y, Oshima T, Takahashi S, Asashima M, Ito Y, Kurabayashi A.
    • Journal Title

      Mitochondrial DNA.

      Volume: 27 Issue: 5 Pages: 3341

    • DOI

      10.3109/19401736.2015.1018213

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Occupancy of tissue-specific cis-regulatory modules by Otx2 and TLE/Groucho for embryonic head specification2014

    • Author(s)
      Yasuoka Y, Suzuki Y, Takahashi S, Someya H, Sudou N, Haramoto Y, Cho KW, Asashima M, Sugano S, Taira M.
    • Journal Title

      Nature Communications

      Volume: 5 Issue: 1 Pages: 4322-4322

    • DOI

      10.1038/ncomms5322

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of the insulin-like growth factor binding protein family in Xenopus tropicalis2014

    • Author(s)
      Haramoto Y, Oshima T, Takahashi S, Yuzuru Ito.
    • Journal Title

      Int. J. Dev. Biol.

      Volume: 58 Issue: 9 Pages: 705-711

    • DOI

      10.1387/ijdb.150032yi

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] ツメガエル後方神経組織の伸長運動は前後組織極性により方向付けられる2014

    • Author(s)
      二宮裕将
    • Organizer
      第9回XCIJ-MA・第8回ツメガエル研究会ジョイント研究集会
    • Place of Presentation
      北里大学相模原キャンパス
    • Year and Date
      2014-11-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 眼の初期発生における転写活性調節に関わる細胞周期依存的なOtx2のリン酸化修飾の役割2014

    • Author(s)
      佐藤 夢子、柴野 卓志、儘田 博志、南 航平、細野 枝里菜、岡田 甫、高橋 秀治、浅島 誠、平良 眞規
    • Organizer
      第37回分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 内胚葉系列の分化を担う発生準備エンハンサーの形成メカニズムの解析2014

    • Author(s)
      今井 紗綾、桐ケ谷 嘉章、安岡 有理、鈴木 穣、高橋 秀治、浅島 誠、菅野 純夫、平良 眞規
    • Organizer
      第37回分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] ツメガエル後方神経組織の伸長運動における前後組織極性の働き2014

    • Author(s)
      二宮裕将
    • Organizer
      第85回日本動物学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Elongation movement of Xenopus posterior neural tissue is directed by anteroposterior tissue polarity2014

    • Author(s)
      Hiromasa Ninomiya
    • Organizer
      15th International Xenopus Conference
    • Place of Presentation
      California, USA
    • Year and Date
      2014-08-24 – 2014-08-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Comparative analysis of insulin-like growth factor binding proteins.2014

    • Author(s)
      Yoshikazu Haramoto, Tomomi Ooshima, Shuji Takahashi, Makoto Asashima, YUzuru Ito
    • Organizer
      15th International Xenopus Conference
    • Place of Presentation
      California, USA
    • Year and Date
      2014-08-24 – 2014-08-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Genomics Study of the Spemann-Mangold Organizer: Occupancy of Tissue-Specific cis-Regulatory Modules by Otx2 and TLE/Groucho for Embryonic Head Specification2014

    • Author(s)
      Yuuri Yasuoka, Yutaka Suzuki, Shuji Takahashi, Haruka Someya, Norihiro Sudou, Yoshikazu Haramoto, Ken Cho, Makoto Asashima, Sumio Sugano, Masanori Taira
    • Organizer
      15th International Xenopus Conference
    • Place of Presentation
      California, USA
    • Year and Date
      2014-08-24 – 2014-08-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Role of anteroposterior tissue polarity in elongation movement of Xenopus posterior neural tissue2014

    • Author(s)
      二宮裕将
    • Organizer
      第47回日本発生生物学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-05-27 – 2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Functional analyses of a novel insulin-like factor2014

    • Author(s)
      原本悦和、高橋秀治(広島大)、小沼泰子、伊藤 弓弦、浅島誠
    • Organizer
      第47回日本発生生物学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-05-27 – 2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Role of anteroposterior tissue polarity in elongation movement of Xenopus posterior neural tissue

    • Author(s)
      Hiromasa Ninomiya
    • Organizer
      47th JSDB meeting (2014 JSDB-APDBN meeting)
    • Place of Presentation
      ウインクあいち(愛知県名古屋市中村区名駅4丁目4-38)
    • Related Report
      2013 Research-status Report
  • [Presentation] イモリ外胚葉層形成のツメガエルとの比較

    • Author(s)
      二宮裕将
    • Organizer
      第7回 日本ツメガエル研究集会
    • Place of Presentation
      秋吉台国際芸術村(山口県美祢市秋芳町秋吉50番地)
    • Related Report
      2013 Research-status Report
  • [Presentation] 新規インスリン様因子の機能解析

    • Author(s)
      原本悦和、高橋秀治、小沼泰子、伊藤弓弦、浅島誠
    • Organizer
      第7回 日本ツメガエル研究集会
    • Place of Presentation
      秋吉台国際芸術村(山口県美祢市秋芳町秋吉50番地)
    • Related Report
      2013 Research-status Report
  • [Presentation] Functional analyses of novel Insulin-like factor

    • Author(s)
      Yoshikazu Haramoto, Shuji Takahashi, Yasuko Onuma,Yuzuru Ito, Makoto Asashima
    • Organizer
      IABHU International Symposium -Frontiers in Amphibian Biology: Endangered Species Conservation and Genome Editing-
    • Place of Presentation
      広島大学理学研究科(広島県東広島市鏡山 1-3-1)
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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