| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
I have studied about whether there are varieties in mechanisms of convergent extension regarding to cell directing role of tissue polarity. Xenopus neural, somitic and human dorsal mesoderm cell masses remained spherical shape in uniform differentiation states (= differentiation without tissue polarity), whereas the tissues elongated into direction of the polarity in biased differentiation states (= differentiation with tissue polarity). These results were consistent with previous experiments in Xenopus notochord tissue. Different combinations of signals induced the tissue polarity in different tissues. These results indicated that 1) "Tissue polarity is directing on convergent extension of the various vertebrate dorsal tissues" and 2) "Tissue polarity is induced by various combinations of signals".
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