Analyses of controlling factors in elongation movements
| Project/Area Number |
24570231
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Shuji 広島大学, 理学系研究科, 特任准教授 (90447318)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 形態形成 / 細胞運動 / 組織分化 / 脊椎動物 / 形態形成運動 / 誘導 / 上皮 |
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| Outline of Final Research Achievements |
I have studied about whether there are varieties in mechanisms of convergent extension regarding to cell directing role of tissue polarity. Xenopus neural, somitic and human dorsal mesoderm cell masses remained spherical shape in uniform differentiation states (= differentiation without tissue polarity), whereas the tissues elongated into direction of the polarity in biased differentiation states (= differentiation with tissue polarity). These results were consistent with previous experiments in Xenopus notochord tissue. Different combinations of signals induced the tissue polarity in different tissues. These results indicated that 1) "Tissue polarity is directing on convergent extension of the various vertebrate dorsal tissues" and 2) "Tissue polarity is induced by various combinations of signals".
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Report
(4 results)
Research Products
(17 results)
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[Presentation] Genomics Study of the Spemann-Mangold Organizer: Occupancy of Tissue-Specific cis-Regulatory Modules by Otx2 and TLE/Groucho for Embryonic Head Specification2014
Author(s)
Yuuri Yasuoka, Yutaka Suzuki, Shuji Takahashi, Haruka Someya, Norihiro Sudou, Yoshikazu Haramoto, Ken Cho, Makoto Asashima, Sumio Sugano, Masanori Taira
Organizer
15th International Xenopus Conference
Place of Presentation
California, USA
Year and Date
2014-08-24 – 2014-08-28
Related Report
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[Presentation] Functional analyses of novel Insulin-like factor
Author(s)
Yoshikazu Haramoto, Shuji Takahashi, Yasuko Onuma,Yuzuru Ito, Makoto Asashima
Organizer
IABHU International Symposium -Frontiers in Amphibian Biology: Endangered Species Conservation and Genome Editing-
Place of Presentation
広島大学理学研究科（広島県東広島市鏡山 1-3-1）
Related Report
