Comprehensive approaches to mechanisms underlying the development of blood islands in amphibian embryo
| Project/Area Number |
24570234
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Niigata University |
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Principal Investigator |
MAENO Mitsugu 新潟大学, 自然科学系, 教授 (10190315)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Takashi 早稲田大学, 教育・総合科学学術院, 教授 (80350388)
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| Co-Investigator(Renkei-kenkyūsha) |
KUMANO Gaku 東北大学, 生命科学研究科, 教授 (80372605)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 器官形成 / 両生類 / 骨髄球 / 中腎 / 血島 / 抗体 / 血管 / 心臓 / ゼノパス / モルフォリノ / 胚 / 転写因子 / 脊椎動物 |
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| Outline of Final Research Achievements |
The present research has attempted to elucidate development of the blood islands and myeloid cells in Xenopus embryo. First, we found a physiological role of Nkx2.5 and GATA4, which are the transcription factors for heart specification, are involved in the myeloid cell differentiation in the anterior blood islands. Second, we showed the distribution of Rdd (repeated D domain-like) protein in the developing embryo. Third, we discovered a novel population of myeloid cells in the mesonephric rudiment at an early tadpole stage.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Quantification and localization of erythropoietin receptor expressing cells in the liver of Xenopus laevis.2013
Author(s)
Okui, T., Yamamoto, Y., Maekawa, S., Nagasawa, K., Yonezuka, Y., Aizawa, Y., Kato, T.
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Journal Title
Cell Tissue Res.
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Hepatic confinement of newly-produced erythrocytes caused by low-temperature exposure in Xenopus laevis.2012
Author(s)
Maekawa, S., Iemura, H., Kuramochi, Y., Nogawa-Kosaka, N., Nishikawa, H., Okui, T., Aizawa, Y., Kato, T.
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Journal Title
J. Exp. Biol.
Volume: 215
Issue: 17
Pages: 3087-3095
DOI
Related Report
Peer Reviewed
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[Presentation] 生物の進化と赤血球造血2014
Author(s)
加藤尚志
Organizer
第76回日本血液学会学術集会
Place of Presentation
大阪国際会議場（大阪市）
Year and Date
2014-10-31 – 2014-11-02
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[Presentation] Biochemical and functional analyses of rdd, novel secretory proteins, in Xenopus embryo.2012
Author(s)
Lim, J. C., Kurihara, S., Tamaki, R., Mashima, Y., Maeno, M.
Organizer
Joint Meeting of JSDB 45th & JSCB 64th
Place of Presentation
Kobe International Conference Center
Related Report
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