| Project/Area Number |
24570234
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Niigata University |
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Principal Investigator |
MAENO Mitsugu 新潟大学, 自然科学系, 教授 (10190315)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Takashi 早稲田大学, 教育・総合科学学術院, 教授 (80350388)
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| Co-Investigator(Renkei-kenkyūsha) |
KUMANO Gaku 東北大学, 生命科学研究科, 教授 (80372605)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 器官形成 / 両生類 / 骨髄球 / 中腎 / 血島 / 抗体 / 血管 / 心臓 / ゼノパス / モルフォリノ / 胚 / 転写因子 / 脊椎動物 |
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| Outline of Final Research Achievements |
The present research has attempted to elucidate development of the blood islands and myeloid cells in Xenopus embryo. First, we found a physiological role of Nkx2.5 and GATA4, which are the transcription factors for heart specification, are involved in the myeloid cell differentiation in the anterior blood islands. Second, we showed the distribution of Rdd (repeated D domain-like) protein in the developing embryo. Third, we discovered a novel population of myeloid cells in the mesonephric rudiment at an early tadpole stage.
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