| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Oct60 gene is Xenopus paralog of mammalian Oct3/4 gene which encodes a transcription factor of POU family class V. In immunohistochemical analysis, the Oct60-expressing cells were detected in adult gonads, liver, kidney and blood cells. The Oct60-expressing cells were stained with anti-Bmi1 antibody and increased in number by anemic induction, suggesting that the Oct60-expressing cells are hematopoietic precursor-like cells. Cell transplantation experiment indicated that the Oct60-expressing cells are derived from dorsolateral mesoderm of tail-bud stage embryos. Functional analysis of Oct60 showed that the Oct60-expressing cells are multipotent undifferentiated cells.
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