An Evo-Devo study for mechanisms of body axis formation in vertebrates
| Project/Area Number |
24570244
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Kawasaki University of Medical Welfare |
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Principal Investigator |
TAKEUCHI Masaki 川崎医療福祉大学, 医療技術学部, 准教授 (00392019)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脊椎動物 / 体軸 / 転写因子 / 条鰭類 / ポリプテルス / ホメオボックス / 両生類 / siamois / 進化 / 初期発生 / 内胚葉 / 体軸形成 / 多様性 |
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| Outline of Final Research Achievements |
Xenopus siamois is a homeobox gene cording for a transcriptional mediator of the dorsal Wnt signaling pathway and is necessary for the head formation. Despite its importance in Xenopus development, no siamois-related genes have been found in other taxa. In this study, I found a novel siamois-related gene, dioskouroi, in bichir. The bichir gene, which is different from siamois, plays roles in not only organizer formation but also endoderm differentiation endogenously. These results lead to a hypothesis that the siamois-related protogene in a common ancestor of bony fishes played central role in early embryogenesis. The protogene as a Wnt signal mediator might be derived into Xenopus siamois which play a role in head formation and bichir dioskouroi which play a role in endoderm differentiation.
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Report
(4 results)
Research Products
(9 results)
