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Elucidation of post-translational regulation of ABCG proteiins

Research Project

Project/Area Number 24580139
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied biochemistry
Research InstitutionKyoto Women's University (2014-2015)
Kyoto University (2012-2013)

Principal Investigator

MATSUO MICHINORI  京都女子大学, 家政学部, 准教授 (00335308)

Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsABCタンパク質 / コレステロール / モジュレーター / 脂質 / トランスポーター / メタボリックシンドローム / 動脈硬化 / アルツハイマー病 / プロテインキナーゼ
Outline of Final Research Achievements

The aim of this study is to elucidate lipid homeostasis in our body by analyzing post-translational regulation of ABCG proteins involved in lipid efflux from cells. Regulation mechanism of ABCG1 and ABCG4 in neuronal cells and functional regulation of ABCG proteins by fatty acids and interacting proteins were demonstrated. The results may lead to prevention and treatment of metabolic syndrome and Alzheimer’s disease.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (28 results)

All 2016 2015 2014 2013 2012 Other

All Journal Article (13 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 13 results,  Open Access: 4 results,  Acknowledgement Compliant: 4 results) Presentation (13 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Possible application of apolipoprotein E-containing lipoproteins and polyunsaturated fatty acids in neural regeneration.2016

    • Author(s)
      Matsuo, M.
    • Journal Title

      Neural Regene. Res.

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] ABCG1 and ABCG4 suppress γ-secretase activity and amyloid β production.2016

    • Author(s)
      Sano, O., Tsujita, M., Shimizu, Y., Kato, R., Kobayashi, A., Kioka, N., Ramaley, A.T.., Michikawa, M., Ueda K., and Matsuo, M.
    • Journal Title

      PLoS ONE

      Volume: 印刷中

    • NAID

      120005997762

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Neurite outgrowth stimulation by n-3 and n-6 PUFAs of phospholipids in apoE-containing lipoproteins secreted from glial cells2015

    • Author(s)
      Nakato M, Matsuo M, Kono N, Arita M, Arai H, Ogawa J, Kioka N, Ueda K.
    • Journal Title

      J Lipid Res

      Volume: 56 Issue: 10 Pages: 1880

    • DOI

      10.1194/jlr.m058164

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Position 834 in TM6 plays an important role in cholesterol and phosphatidylcholine transport by ABCA12015

    • Author(s)
      Shimpei Ito, Kohjiro Nagao, Yasuhisa Kimura, Michinori Matsuo, Noriyuki Kioka, Kazumitsu Ueda
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 79 Issue: 5 Pages: 775-781

    • DOI

      10.1080/09168451.2014.993358

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ABCB4 exports phosphatidylcholine in a sphingomyel-independent manner2015

    • Author(s)
      Zhao, Y., Ishigami, M., Nagao, K., Hanada, K., Kono, N., Arai, H., Matsuo, M., Kioka, N., and Ueda, K.
    • Journal Title

      J. Lipid Res.

      Volume: 56 Issue: 3 Pages: 644

    • DOI

      10.1194/jlr.m056622

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Loss of Dlg5 expression promotes the migration and invasion of prostate cancer cells via Girdin phosphorylation2014

    • Author(s)
      Tomiyama, L., Sezaki, T., Matsuo, M., Ueda, K. and Kioka, N.
    • Journal Title

      Oncogene

      Volume: 33 Issue: 9 Pages: 1141-1149

    • DOI

      10.1038/onc.2014.31

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ABCA1, ABCG1, and ABCG4 are distributed to distinct membrane meso-domains and disturb detergent-resistant domains on the plasma membrane2014

    • Author(s)
      Sano, O., Ito, S., Kato, R., Shimizu, Y., Kobayashi, A., Kimura, Y., Kioka, N., Hanada, K., Ueda K., and Matsuo, M.
    • Journal Title

      PLoS ONE

      Volume: 9 Issue: 10 Pages: e109886-e109886

    • DOI

      10.1371/journal.pone.0109886

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Fomiroid A, a novel compound from the mushroom Fomitopsis nigra, inhibits NPC1L1-mediated cholesterol uptake via a mode of action distinct from that of ezetimibe2014

    • Author(s)
      Chiba, T., Sakurada, T., Watanabe, R., Yamaguchi, K., Kimura, Y. Kioka, N., Kawagishi, H., Matsuo, M., and Ueda K
    • Journal Title

      PLoS ONE

      Volume: 9 Issue: 12 Pages: e116162-e116162

    • DOI

      10.1371/journal.pone.0116162

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 24(S)-hydroxycholesterol is actively eliminated from neuronal cells by ABCA1.2013

    • Author(s)
      Matsuda, A., Nagao, K, Matsuo, M., Kioka N. and Ueda, K.
    • Journal Title

      J. Neurochem.

      Volume: (in press) Issue: 1 Pages: 93-101

    • DOI

      10.1111/jnc.12275

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] ATPase activity of nucleotide binding domains of human MDR3 in the context of MDR12013

    • Author(s)
      Ishigami, M.. Tominaga, Y., Nagao, K., Kimura, Y., Matsuo, M., Kioka, N. and Ueda, K
    • Journal Title

      Biochim Biophys Acta-MCBL

      Volume: 1831 Issue: 4 Pages: 683-690

    • DOI

      10.1016/j.bbalip.2012.12.016

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] ATPase activity of human ABCG1 is stimulated by cholesterol and sphingomyelin.2013

    • Author(s)
      Hirayama, H., Kimura, Y., Kioka, N., Matsuo,M. and Ueda, K.
    • Journal Title

      J. Lipid Res.

      Volume: 54 Issue: 2 Pages: 496-502

    • DOI

      10.1194/jlr.m033209

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of Dlg5/1p-dlg, a membrane-associated guanylate kinase family protein, in epithelial-mesenchymal transition in LLc-PK1 renal epithelial cells2012

    • Author(s)
      Takuhito Sezaki, Kohki Inada, Takayuki Sogabe, Kumiyo Kakuda, Lucia Tomiyama, Yohsuke Matsuno, Takafumi Ichikawa, Michinori Matsuo, Kazumitsu Ueda, Noriyuki Kioka
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 4 Pages: e35519-e35519

    • DOI

      10.1371/journal.pone.0035519

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] ATP hydrolysis-dependent conformational changes in the extracellular domain of ABCA1 are associated with apoA-I binding.2012

    • Author(s)
      Nagao, K., Takahashi, K., Azuma, Y., Takada, M., Kimura, Y., Matsuo, M., Kioka, N. and Ueda, K.
    • Journal Title

      J Lipid Res

      Volume: 53 Issue: 1 Pages: 126-136

    • DOI

      10.1194/jlr.m019976

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Phosphorylation by protein kinase C stabilizes ABCG12016

    • Author(s)
      Michinori Matsuo, Taro Watanabe, and Kazumitsu Ueda
    • Organizer
      6th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases”
    • Place of Presentation
      インスブルク(オーストリア)
    • Year and Date
      2016-03-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 多価不飽和脂肪酸を含有するグリア細胞由来リポタンパク質の神経突起伸長作用2015

    • Author(s)
      松尾道憲、中塔充宏、植田和光
    • Organizer
      BMB2015
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 多価不飽和脂肪酸含有リポタンパク質は神経突起伸長を促進する2015

    • Author(s)
      松尾道憲、中塔充宏、植田和光
    • Organizer
      第10回トランスポーター研究会
    • Place of Presentation
      東京
    • Year and Date
      2015-06-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] Polyunsaturated fatty acids in lipoproteins stimulate neurite outgrowth of hippocampal neurons2015

    • Author(s)
      Michinori Matsuo, Mitsuhiro Nakato, and Kazumitsu Ueda
    • Organizer
      12th Asian Congress of Nutrition (12th ACN)
    • Place of Presentation
      横浜
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ABCトランスポーターの膜脂質ラフトへの分布とアミロイド前駆体タンパク質のプロセシングに与える効果2014

    • Author(s)
      松尾 道憲、佐野修、伊藤志保、加藤玲子、清水裕二、植田和光
    • Organizer
      第36回 生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      徳島大学(徳島市)
    • Year and Date
      2014-11-21
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] コレステロールを輸送するABCG1の新規機能2014

    • Author(s)
      松尾 道憲、渡邊太郎、平井絢子、植田 和光
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都国際会館(京都市)
    • Year and Date
      2014-10-17
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] プロテインキナーゼCによるABCG1の調節2014

    • Author(s)
      松尾道憲、渡邊太郎、植田和光
    • Organizer
      第9回トランスポーター研究会年会
    • Place of Presentation
      名古屋市立大学(名古屋市)
    • Year and Date
      2014-06-14
    • Related Report
      2014 Research-status Report
  • [Presentation] オメガ3脂肪酸によるリポタンパク質の質的制御を介した生理作用2014

    • Author(s)
      松尾 道憲、斉藤 貴将、中塔 充宏、木岡 紀幸、小川 順、植田 和光
    • Organizer
      農芸化学会2014年度大会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Regulation of HMG-CoA reductase activity by ABCG12014

    • Author(s)
      Michinori Matsuo, Taro Watanabe, Ayako Hirai, and Kazumitsu Ueda
    • Organizer
      5th FEBS special meeting
    • Place of Presentation
      Innsbruck, Austria
    • Related Report
      2013 Research-status Report
  • [Presentation] プロテインキナーゼCによるABCG1のリン酸化解析2013

    • Author(s)
      松尾道憲、渡邊太郎、植田和光
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] ABC48-ヒトABCトランスポーター発現系ライブラリーの構築と細胞内局在の解析―2013

    • Author(s)
      松尾道憲、福田麻菜、植田和光
    • Organizer
      第8回トランスポーター研究会年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report
  • [Presentation] Phosphorylation by protein kinase C stabilizes ABCG12013

    • Author(s)
      Michinori Matsuo, Taro Watanabe, Kazumitsu Ueda
    • Organizer
      The Fourteenth International Membrane Research Forum
    • Place of Presentation
      Kyoto
    • Related Report
      2012 Research-status Report
  • [Presentation] ABC proteins regulate the integrity of membrane meso-domains2012

    • Author(s)
      Michinori Matsuo, Hiromune Ando, Makoto Kiso, and Kazumisu Ueda
    • Organizer
      iCeMS retreat
    • Place of Presentation
      Osaka
    • Related Report
      2012 Research-status Report
  • [Book] トランスポーターと疾患研究の最前線2013

    • Author(s)
      松尾道憲
    • Total Pages
      160
    • Publisher
      医歯薬出版
    • Related Report
      2013 Research-status Report
  • [Remarks] 細胞生化学研究室

    • URL

      http://cseika-1.kais.kyoto-u.ac.jp/

    • Related Report
      2013 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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