| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Oxygen is essential for aerobic organisms, but generates reactive oxygen species (ROS), which can cause cellular dysfunction that would accelerate aging and diseases. We have analyzed the genes involved in the generation or the quenching of ROS in the nematode Caenorhabditis elegans and the yeast Saccharomyces cerevisiae as model organisms. In this study, we have successfully identified the gene involved in the regulation of oxidative stress sensitivity in C. elegans and characterized the function of the gene, which confers oxidative stress resistance, when overexpressed, in S. cerevisiae. We also screened for bioactive compounds that show a protective effect on oxidative stress in C. elegans.
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