| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Outline of Final Research Achievements |
Japanese oak wilt (JOW) is a tree disease caused by the fungus Raffaelea quercivora, which is vectored by the ambrosia beetle, Platypus quercivorus. In this study, 15 compounds were isolated from the endophytes, Cytospora sp. TT-10 and Microdiplodia sp. TT-12 isolated from JOW, and a culture of commercial edible mushroom, Hypsizygus marmoreus. Phomadecalin F, 8α-monoacetoxyphomadecalin D, 3-epi-phomadecalin D, 13-hydroxylmacroforin A were isolated from the culture of Microdiplodia sp. TT-12, 4,5-dihydroxy-3-heptylphthalide and named cytosporone E, integracin A, cytosporones N and A from Cytospora sp. TT-10, and 2(E)-decene-4,6,8-triyn-1-ol and decene-4,6,8-triyn-1-ol and 8(E)-decene-4,6-diyn-1,2,10-triol from a liquid culture of Hypsizygus marmoreus. Among them, integracin A, 13-hydroxylmacroforin A and 2(E)-decene-4,6,8-triyn-1-ol exhibited antifungal activity against the pathogenic fungus Raffaelea quercivora due to JOW.
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