| Project/Area Number |
24580156
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
IRIE Kazuhiro 京都大学, 大学院農学研究科, 教授 (00168535)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | アミロイドβ凝集阻害活性 / アルツハイマー病 / Th-T / カフェ酸誘導体 / HGF産生促進活性 / サツマイモ / コーヒー / 神経細胞保護作用 / Aβ凝集阻害活性 / アルツハイマー症 / キノコ / 地骨皮 / ビスフラボノイド / HGF / カフェオイルキナ酸 / フェニルエタノイド配糖体 / 記憶障害改善 / プロポリス |
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| Outline of Final Research Achievements |
Alzheimer’s disease (AD) is one of the most common forms of dementia. Amyloid β-proteins (Aβ) are considered to play an important role in the pathogenesis of AD. Caffeoylquinic acids (CQA) contained in the sweet potato and coffee, etc. exhibited potent inhibitory activity of the aggregation of Aβ. The catechol moiety in CQAs was indicated important role for the activity by structure-activity relationship of CQAs and related compounds. On the other hand, phenylethanoid glycosides included in the olive etc. were isolated as the active compounds using the Aβ aggregation inhibition test such as Thioflavin-T method. In addition, these Aβ aggregation inhibitors showed potent promotion activity of hepatocyte growth factor (HGF). Therefore, these bioactive compounds exhibit potent neuroprotective effect by their Aβ aggregation inhibitory activity, antioxidant activity, and HGF promotion activity.
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