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Responses and fluctuation of endogenous factors by a neural hormone network in insect feeding behavior

Research Project

Project/Area Number 24580157
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Bioproduction chemistry/Bioorganic chemistry
Research InstitutionThe University of Tokyo

Principal Investigator

NAGATA Shinji  東京大学, 新領域創成科学研究科, 准教授 (40345179)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords昆虫生理学 / ペプチド / ホルモン / 摂食行動 / 昆虫生理生化学 / 昆虫 / ペプチドホルモン / ネットワーク
Outline of Final Research Achievements

We have identified the factors modulating insect feeding behavior in the silkworm, so far. Becaus of the data which no crucial factor capable of controlling feeding behavior havet been identified, we assumed that a hormone network should modulate the motivation of feeding behavior in insects. To address the hormone network at a molecular level, we have investigated several basic analyses during this project. As results, we have identified receptors for ITP (ion transport peptide: functional unknown peptide), and unknown peptide factors GSRYamides. In addition, brain-gut peptides can modulate feeding behavior like other animal systems via controlling intestinal metabolisms.
Now, we are generating a network graph for hormones modulating feeding behavior. That evaluation method will contribute to further understanding the hormone network-modulating feeding behavior.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (35 results)

All 2015 2014 2013 2012 Other

All Journal Article (8 results) (of which Peer Reviewed: 7 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (26 results) (of which Invited: 5 results) Remarks (1 results)

  • [Journal Article] Structural determination of an N-glycan moiety attached to the prothoracicotropic hormone from the silkmoth Bombyx mori.2014

    • Author(s)
      Nagata S, Kobayashi J, Kataoka H, Suzuki A.
    • Journal Title

      Biosci, Biotech Biochem

      Volume: 78 Issue: 8 Pages: 1381-1383

    • DOI

      10.1080/09168451.2014.925777

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Identification and characterization of receptors for ion transport peptide (ITP) and ITP-like (ITPL) in the silkworm, Bombyx mori2014

    • Author(s)
      Nagai C, Mabashi AH, Nagasawa H, Nagata S.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 289 Issue: 46 Pages: 32166-32177

    • DOI

      10.1074/jbc.m114.590646

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Mating changes the female dietary preference in the two-spotted cricket, Gryllus bimaculatus2014

    • Author(s)
      塚本悠介、片岡宏誌、長澤寛道、永田晋治
    • Journal Title

      Frontiers in Physiology

      Volume: 5

    • DOI

      10.3389/fphys.2014.00095

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 昆虫の行動を制御するホルモンの研究の最近の動向2013

    • Author(s)
      永田晋治
    • Journal Title

      化学と生物

      Volume: 51 Pages: 168-176

    • NAID

      10031156787

    • Related Report
      2012 Research-status Report
  • [Journal Article] Knockdown of the adipokinetic hormone receptor increases feeding frequency in the two-spotted cricket Gryllus bimaculatus.2012

    • Author(s)
      Konuma T, Morooka N, Nagasawa H, Nagata S
    • Journal Title

      Endocrinology

      Volume: 153 Issue: 7 Pages: 3111-3122

    • DOI

      10.1210/en.2011-1533

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of cDNAs encoding allatotropin and allatotropin-like peptides from the silkworm2012

    • Author(s)
      Nagata S, Matsumoto S, Mizoguchi A, Nagasawa H
    • Journal Title

      Bombyx mori. Peptides

      Volume: 34 Issue: 1 Pages: 98-105

    • DOI

      10.1016/j.peptides.2012.01.002

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of starvation on brain short neuropeptide F-1,-2 and-3 levels and short neuropeptide F receptor expression levels of the siilkworm, Bombyx mori2012

    • Author(s)
      Nagata S, Matsumoto S, Nakane T, Ohara A, Morooka N, Konuma T, Nagai C, Nagasawa H
    • Journal Title

      Frontiers Experimental Endocrinology

      Volume: 3 Pages: 1-3

    • DOI

      10.3389/fendo.2012.00003

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A hemolymph major anionic peptide, HemaP, motivates feeding behavior in the sweetpotato hornworm, Agrius convolvuli2012

    • Author(s)
      諸岡信克、永田晋治、白井孝治、木口憲爾、長澤寛道
    • Journal Title

      FEBS Journal

      Volume: 279 Issue: 1 Pages: 168-179

    • DOI

      10.1111/j.1742-4658.2011.08408.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] RNA-sequencing解析によるフタホシコオロギGryllus bimaculatusの脳神経系ペプチドの同定2015

    • Author(s)
      永田晋治、塚本悠介、鈴木穣
    • Organizer
      日本農芸化学会
    • Place of Presentation
      岡山大学
    • Year and Date
      2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] フタホシコオロギGryllus bimaculatusにおけるアラトスタチンBタイプによる摂食行動の制御機構の解明2015

    • Author(s)
      塚本悠介、永田晋治
    • Organizer
      日本農芸化学会
    • Place of Presentation
      岡山大学
    • Year and Date
      2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] フタホシコオロギGryllus bimaculatusの脂肪酸不飽和化酵素Δ9-およびΔ12-desaturaseの発現変動解析2015

    • Author(s)
      福村圭介、小沼貴裕、永田晋治
    • Organizer
      日本農芸化学会
    • Place of Presentation
      岡山大学
    • Year and Date
      2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] フタホシコオロギGryllus bimaculatusにおける自然免疫にかかわる転写因子のdorsalの同定2015

    • Author(s)
      伊藤尚子、永田晋治
    • Organizer
      日本農芸化学会
    • Place of Presentation
      岡山大学
    • Year and Date
      2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Comprehensive analyses of neuropeptides in the response to different feeding states in the two-spotted cricket, Gryllus bimaculatus2015

    • Author(s)
      塚本悠介、永田晋治
    • Organizer
      Invertebrate neuropeptide conference 2015
    • Place of Presentation
      ミャンマー国、バガン
    • Year and Date
      2015-02-16 – 2015-02-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Comparative analyses of neuropeptides from the silkworm, Bombyx mori and the two-spotted cricket, Gryllus bimaculatus2015

    • Author(s)
      永田晋治、塚本悠介
    • Organizer
      Invertebrate neuropeptide conference 2015
    • Place of Presentation
      ミャンマー国、バガン
    • Year and Date
      2015-02-16 – 2015-02-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 昆虫の摂食行動の内分泌制御が支配する生命維持装置2014

    • Author(s)
      永田晋治
    • Organizer
      生物機能開発学セミナー
    • Place of Presentation
      広島大学
    • Year and Date
      2014-12-02
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 昆虫における栄養分依存的な摂食行動ー内分泌系が支える生命維持装置ー2014

    • Author(s)
      永田晋治
    • Organizer
      茨城大学農医連携シンポジウム
    • Place of Presentation
      茨城大学
    • Year and Date
      2014-09-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 昆虫の摂食行動の内分泌制御2014

    • Author(s)
      永田晋治
    • Organizer
      日本学術会議公開シンポジウム「昆虫における刺激の受容とその反応」
    • Place of Presentation
      日本学術会議講堂
    • Year and Date
      2014-07-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] カイコBombyx moriの糞中に含まれる新規ペプチドおよびタンパク質の同定2013

    • Author(s)
      永田晋治、長澤寛道
    • Organizer
      平成25年度蚕糸昆虫機能利用学術講演会
    • Place of Presentation
      農林水産技術会議事務局筑波事務所
    • Related Report
      2012 Research-status Report
  • [Presentation] Identification of diuretic hormone 31 as a modulator of feeding behavior in the silkworm, Bombyx mori2013

    • Author(s)
      永田晋治、長澤寛道
    • Organizer
      Invertebrate neuropeptide conference 2013
    • Place of Presentation
      Krabi, Thailand
    • Related Report
      2012 Research-status Report
  • [Presentation] 昆虫の行動を規定する化学2012

    • Author(s)
      永田晋治
    • Organizer
      日本農芸化学会関東支部2012年度第1回支部例会
    • Place of Presentation
      東京大学農学部中島記念ホール
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Endocrinal control of nutrional dependent feeding behavior in insects2012

    • Author(s)
      永田晋治
    • Organizer
      日本味と匂い学会
    • Place of Presentation
      大阪大学コンベンションセンター
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Identification of peptidyl factors modulating feeding behavior of the silkworm, Bombyx mori2012

    • Author(s)
      永田晋治、長澤寛道
    • Organizer
      International Conference Entomologist 2012
    • Place of Presentation
      Daegu, Korea
    • Related Report
      2012 Research-status Report
  • [Presentation] Eff ects of knockdown of the adipokinetic hormone receptor on nutritional levels and feeding frequency in the2012

    • Author(s)
      小沼貴裕、諸岡信克、長澤寛道、永田晋治
    • Organizer
      International Conference Entomologist 2012
    • Place of Presentation
      Daegu, Korea
    • Related Report
      2012 Research-status Report
  • [Presentation] フタホシコオロギGryllus bimaculatus の脂肪酸不飽和化酵素 delta 9-および delta 12-desaturaseのクローニングと酵素活性測定

    • Author(s)
      小沼貴裕、安保貴子、吉永直子、森直樹、長澤寛道、永田晋治
    • Organizer
      日本農芸化学会
    • Place of Presentation
      明治大学
    • Related Report
      2013 Research-status Report
  • [Presentation] フタホシコオロギにおける摂食行動を制御する神経ペプチドの網羅的変動解析

    • Author(s)
      塚本悠介、永田晋治
    • Organizer
      日本農芸化学会
    • Place of Presentation
      明治大学
    • Related Report
      2013 Research-status Report
  • [Presentation] フタホシコオロギの選好性摂食行動の自動計測システム作成

    • Author(s)
      永田晋治
    • Organizer
      日本農芸化学会
    • Place of Presentation
      明治大学
    • Related Report
      2013 Research-status Report
  • [Presentation] カイコの摂食行動調節ペプチドGSRYアミドの受容体の同定と解析

    • Author(s)
      永田晋治
    • Organizer
      日本蚕糸昆虫学術講演会
    • Place of Presentation
      日本大学
    • Related Report
      2013 Research-status Report
  • [Presentation] カイコの前額神経球における摂食行動を調節するペプチドホルモンおよびその受容体の発現解析

    • Author(s)
      永田晋治
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] カイコ幼虫における short neuropeptide F による腸管由来消化酵素の調節

    • Author(s)
      永田晋治、大原彩子、長澤寛道
    • Organizer
      日本比較内分泌学会
    • Place of Presentation
      宮崎市民プラザ
    • Related Report
      2013 Research-status Report
  • [Presentation] カイコBombyx moriの前額神経球に発現しているペプチドホルモン利尿ホルモン31は幼虫の摂食行動を調節する

    • Author(s)
      永田晋治、長澤寛道
    • Organizer
      日本分子生物学会
    • Place of Presentation
      福岡マリンメッセ
    • Related Report
      2012 Research-status Report
  • [Presentation] カイコにおける神経ペプチドshort neuropeptide Fが中腸のプロテアーゼ活性に与える影響

    • Author(s)
      大原彩子、永田晋治、長澤寛道
    • Organizer
      日本農芸化学会平成25年度大会
    • Place of Presentation
      東北大学
    • Related Report
      2012 Research-status Report
  • [Presentation] フタホシコオロギ(Gryllus bimaculatus)における脂質動員ホルモン(AKH, adipokinetic hormone)が制御する体液中の脂質および糖質レベルと摂食行動との関連性の解析

    • Author(s)
      小沼貴裕、永田晋治、長澤寛道
    • Organizer
      日本農芸化学会平成25年度大会
    • Place of Presentation
      東北大学
    • Related Report
      2012 Research-status Report
  • [Presentation] フタホシコオロギにおける交尾後に惹起される摂食行動に関わる生体内因子の同定の試み

    • Author(s)
      塚本悠介、永田晋治、長澤寛道
    • Organizer
      日本農芸化学会平成25年度大会
    • Place of Presentation
      東北大学
    • Related Report
      2012 Research-status Report
  • [Presentation] フタホシコオロギのおける餌に含まれる共食いを抑制する因子の同定の試み

    • Author(s)
      永田晋治、長澤寛道
    • Organizer
      日本農芸化学会平成25年度大会
    • Place of Presentation
      東北大学
    • Related Report
      2012 Research-status Report
  • [Remarks] 東大院新領域創成科学研究科先端生命科学専攻 分子認識化学分野 Team N 「昆虫の摂食行動」

    • URL

      https://sites.google.com/site/teamnagata2013/home

    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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