| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Synthesis of solanoeclepin A, the most active hatching agent of potato cyst nematode isolated from hydroponic potato cultures was examined not only for the chemical supply of solanoeclepin A but also for the structure-activity relationship study. As a result, we have demonstrated the power of 4-exo-trig radical cyclization for construction of the highly strained cyclobutane found in solanoeclepin A. Since the substrate is readily prepared from Hajos-Parrish ketone, samarium(II)-mediated 4-exo-trig radical cyclization could provide one of the most straightforward accessible routes to the tricyclo[5.2.1.01,6]decane skeleton of solanoeclepin A.
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