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Effects of irregular eating on the hepatic inflammatory response in mice

Research Project

Project/Area Number 24580174
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Food science
Research InstitutionChiba University

Principal Investigator

OARADA MOTOKO  千葉大学, 真菌医学研究センター, 助教 (40211784)

Co-Investigator(Kenkyū-buntansha) GONOI Tohru  千葉大学, 真菌医学研究センター, 教授 (30134365)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords栄養学 / 食生活 / 肝臓 / 炎症 / 復食 / 炭水化物 / グルコース / 炎症反応 / 生活習慣病 / TLR2
Outline of Final Research Achievements

Unhealthy eating behaviors increase the risk of metabolic diseases, but the underlying mechanisms are not fully elucidated. Because inflammation contributes to the pathogenesis of metabolic diseases, the objective of our present study was to address the effects of a fasting-refeeding regime, a model of irregular eating, on the hepatic inflammatory responses in mouse. Refeeding with a standard diet increased the liver expression of Tlr2 and proinflammatory mediators. These increases were attenuated in mice refed a low-carbohydrate/high-fat diet. TLR2 deficiency significantly attenuated the refeeding-induced increase in the liver expression of inflammatory genes. Dietary glucose, rather than fructose, plays a significant role in this increase. These findings suggest that an irregular eating behavior can elicit a liver inflammatory response, which is at least partly mediated by TLR2, and that dietary carbohydrates play critical roles in this process.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (5 results)

All 2015 2013

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 1 results) Presentation (1 results) (of which Invited: 1 results)

  • [Journal Article] Refeeding with glucose rather than fructose elicits greater hepatic inflammatory gene expression in mice2015

    • Author(s)
      Oarada M, et al.
    • Journal Title

      Nutrition

      Volume: 31 Issue: 5 Pages: 757-65

    • DOI

      10.1016/j.nut.2014.11.014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Refeeding with a standard diet after a 48-h fast elicits an inflammatory response in the mouse liver.2013

    • Author(s)
      Oarada M, et al.
    • Journal Title

      J Nutr Biochem

      Volume: 24 Pages: 1314-23

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Refeeding with a standard diet after a 48-h fast elicits an inflammatory response in the mouse liver.2013

    • Author(s)
      Oarada M, Miki T, Kohno S, Sakai K, Nikawa T, Yoneyama M, Gonoi T.
    • Journal Title

      J Nutr Biochem

      Volume: 62 Pages: 1-15

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cbl-b is a critical regulator of macrophage activation associated with obesity-induced insulin resistance in mice.2013

    • Author(s)
      Abe T, Hirasaka K, Kagawa S, Kohno S, Ochi A, Utsunomiya K, Sakai A, Ohno A, Teshima-Kondo S, Okumura Y, Oarada M, Maekawa Y, Terao J, Mills EM, Nikawa T.
    • Journal Title

      Diabetes

      Volume: 24 Pages: 1-10

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 不規則な食事と肝機能2013

    • Author(s)
      大荒田素子
    • Organizer
      日本食品免疫学会
    • Place of Presentation
      東京大学
    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Invited

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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