Regulation of intestinal epithelial glucose transporter by food factors to prevent or improve metabolic syndrome
| Project/Area Number |
24580176
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Maebashi Institute of Technology (2014)
The University of Tokyo (2012-2013) |
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Principal Investigator |
SATSU HIDEO 前橋工科大学, 工学部, 准教授 (80323484)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | トランスポーター / 腸管上皮細胞 / フィトケミカル / 生活習慣病 / 糖質 / フルクトース / グルコース / GLUT5 / SGLT1 / 単糖 |
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| Outline of Final Research Achievements |
We analyzed the food substances that inhibit intestinal monosaccharide absorption to prevent the diseases caused by excessive carbohydrates. We searched for phytochemicals that inhibit glucose transporter SGLT1, responsible for glucose absorption, and also GLUT5, responsible for fructose absorption. We found that tangeretin contained in citrus fruits and epicatechin gallate contained in green tea inhibited SGLT1 and GLUT5 activity. Oral glucose tolerance test using mice showed that tangeretin significantly suppressed the increase in mouse blood glucose level.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Induction of NAD(P) H : quinone oxidoreductase 1 expression by cysteine via Nrf2 activation in human intestinal epithelial LS180 cells2012
Author(s)
Satsu, H., Chidachi, E., Hiura, Y., Ogiwara, H., Gondo, Y., and Shimizu, M.
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Journal Title
Amino Acids, in press
Volume: (印刷中)
Issue: 4
Pages: 1547-1555
DOI
Related Report
Peer Reviewed
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[Presentation] タウリンと腸管吸収・機能2015
Author(s)
薩 秀夫、清水 誠
Organizer
第１回国際タウリン研究会日本部会
Place of Presentation
兵庫医療大学
Year and Date
2015-02-21 – 2015-02-22
Related Report
Invited
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