Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Outline of Final Research Achievements |
Matriptase is a transmembrane serine protease. In this study, we found that low-density lipoprotein receptor class A domain repeat in the stem domain of matriptase acts to enhance its zymogen activity and that some kinds of divalent cations are required for the expression of zymogen activity. In addition, we obtained evidence supporting that the activation of matriptase zymogen occurs by a mechanism requiring the interaction of the two molecules (transactivation).
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