Elucidation of the mechanism of matriptase activation and exploration of food components that control the activation.
| Project/Area Number |
24580178
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kyoto University |
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Principal Investigator |
TSUZUKI Satoshi 京都大学, (連合)農学研究科(研究院), 助教 (50283651)
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| Co-Investigator(Renkei-kenkyūsha) |
INOUYE Kuniyo (10223249)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 酵素 / 食品 / 遺伝子 / バイオテクノロジー / 栄養学 |
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| Outline of Final Research Achievements |
Matriptase is a transmembrane serine protease. In this study, we found that low-density lipoprotein receptor class A domain repeat in the stem domain of matriptase acts to enhance its zymogen activity and that some kinds of divalent cations are required for the expression of zymogen activity. In addition, we obtained evidence supporting that the activation of matriptase zymogen occurs by a mechanism requiring the interaction of the two molecules (transactivation).
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Report
(4 results)
Research Products
(4 results)
