| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
We investigated the effect of pomegranate arils on survival of beneficial intestinal bacteria (Bifidobacterium longum) to improve the intestinal microbial balance. The aril extract showed the survival effect on B. longum. We explored metabolites derived from gallagyl moiety in rat urine after administration of punicalagin. Urolithin A was observed 12-96 h after the ingestion of punicalagin, suggesting that a hexahydroxydiphenoyl group in the molecule was converted to urolithin A. We further investigated the isolation and structure elucidation of bioactive constituents from edible pomegranate arils. Two new ellagitannin oligomers, pomegraniins A and B, a new glucose ester of neolignan, pomegralignan, and 6-O-(4-hydroxybenzoyl)-1-O-galloylglucose were isolated from the arils of pomegranate. Six known ellagitannins were also isolated from the pericarps of pomegranate. The structures of the new compounds were determined by spectroscopic analyses and chemical evidence.
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