Glucose tolerance improvement effect of resistant starch -4: Is ileum and colon brake involved! ?

• Project/Area Number: 24580187
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Food science
• Research Institution: Osaka Aoyama University (2013-2014); Ehime University (2012)
• Principal Investigator: EBIHARA Kiyoshi 大阪青山大学, 健康科学部, 教授 (90036492)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: レジスタント スターチ タイプ４ / 耐糖性改善効果 / 血糖値 / インスリン / インクレチン / 短鎖脂肪酸 / レジスタントスターチ・タイプ４ / GLP-1 / PYY / 回腸ブレーキ / 結腸ブレーキ / レジスタントスターチタイプ４ / 耐糖性作用

Outline of Final Research Achievements

Resistant starch is highly resistant to α-amylase digestion and is subdivided into 4 categories (RS type 1- type 4). The use of RS enables fortification of many foods with a dietary fiber-like material. Resistant starch type 4 (RS-4) is chemically or physically modified starch and is used in many food industries to improve the physical properties of various products.
RS-4 showed an improving effect of glucose tolerance and a delaying effect of diabetes onset through stimulating the incretin secretion from the ileum and colon. The stimulating effect of RS-4 on incretin secretion was strongly related to the amount of short chain fatty acids produced by bacteria fermentaion of RS-4 in the large intestines. The incretin such as GLP-1 (glucagon-like peptide-1) and PYY (peptide YY)is hormone secreted from the gut in response to food and stimulates the secretion of insulin. The stimulating effect of RS-4 on incretin secretion depended on the degree of fermentation of the RS-4.

Research Products

• [Journal Article] 教材研究 テジスタントスターチの栄養・生理機能 (2014)
  • Author(s): 海老原 清
  • Journal Title: 日本調理科学雑誌 Volume: 47 Pages: 49-52
• [Journal Article] 総説 レジスタントスターチ・タイプ４の栄養・生理機能について (2014)
  • Author(s): 海老原 清
  • Journal Title: 食品加工技術 Volume: 34 Pages: 34-42
• [Journal Article] Hydroxypropylation of high-amylose maize starch changes the digestion and fermentation-dependent parameters in rats (2013)
  • Author(s): Kiyoshi Ebihara, Natsumi Kaneko, Taro Kishida
  • Journal Title: Journal of Nutritional Science Volume: 2 Pages: 1-8
  • Peer Reviewed
• [Presentation] Plasma GLP-1 concentration and dipeptidyl peptidase-4 activity in rats fed partially hydrolyzed guar gum, fermentable dietary fiber, are decreased by cecectomy (2015)
  • Author(s): Ryoko Shimada, Yoko Segawa-Katayama, Kiyoshi Ebihara
  • Organizer: 6th International Dietary Fibre Conference 2015, DF 2015
  • Place of Presentation: Paris
  • Year and Date: 2015-06-01 – 2015-06-03
• [Presentation] Plasma GLP-1 concentration is increased in non-operated rats fed fermentable dietary fiber, but not in cecectomized rats (2015)
  • Author(s): Ryoko Shimada, Yoko Segawa-Katayama, Kiyoshi Ebihara
  • Organizer: 12th Asian Congress of Nutrition
  • Place of Presentation: 横浜
  • Year and Date: 2015-05-14 – 2015-05-18
• [Presentation] 食物繊維の栄養・生理機能について (2014)
  • Author(s): 海老原 清
  • Organizer: 第７７回醤油研究発表会
  • Place of Presentation: 愛媛県松山市
  • Invited
• [Presentation] レジスタントスターチ・タイプ４の栄養・生理機能 (2013)
  • Author(s): 海老原 清
  • Organizer: 第５３回日本澱粉研究懇談会
  • Place of Presentation: 静岡県伊東市
  • Invited
• [Presentation] レジスタントスターチ・タイプ４の栄養・生理機能について (2013)
  • Author(s): 海老原 清
  • Organizer: 日本食品・機械研究会 第１１回高付加価値食品開発のためのフォーラム
  • Place of Presentation: 静岡県富士裾野市
  • Invited
• [Presentation] レジスタントスターチの栄養・生理機能
  • Author(s): 海老原 清
  • Organizer: 第５３回澱粉研究懇談会
  • Place of Presentation: 伊東市
  • Invited
• [Presentation] レジスタントスターチの栄養・生理機能
  • Author(s): 海老原 清
  • Organizer: 日本食品・機械研究会
  • Place of Presentation: 静岡県裾野市
  • Invited