Appetite decreasing effect of soy isoflavone by novel mechanism via intestine

• Project/Area Number: 24580189
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Food science
• Research Institution: Ehime University
• Principal Investigator: KISHIDA Taro 愛媛大学, 農学部, 教授 (80304658)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 食物繊維 / 摂取エネルギー / レプチン / 視床下部 / ラット / イソフラボン / 大豆 / 食欲 / エストロゲン / 神経伝達物質

Outline of Final Research Achievements

Equol concentration in bile was higer than serum. The injected bile collected from rats fed daidzein significantly decreased food intake 12h after injection. After injection, the intestinal gene expression of CCK significantly increased and insignificant trend was observed in the gene expression of preproglucagon and peptide YY. Contrary to theresult in (2), we found that dietary equol decreased food intake regardress of CCKreceptor deficiency. CCK might not be a contributing factor in the mechanism of equol on decreased food intake in female rats.

Research Products

• [Journal Article] The daidzein- and estradiol- induced anorectic action in CCK or leptin receptor deficiency rats (2015)
  • Author(s): Mina Fujitani, Takafumi Mizushige, Keshab Bhattarai, Asami Iwahara, Ryojiro Aida, Taro Kishida
  • Journal Title: Bioscience, Biotechnology and Biochemistry Volume: 未定
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Dynamics of appetite-mediated gene expression in daidzein-fed female rats in the meal-feeding method (2015)
  • Author(s): Mina Fujitani, Takafumi Mizushige, Keshab Bhattarai, Asami Iwahara, Ryojiro Aida, Tomomi Segawa, Taro Kishida
  • Journal Title: Bioscience, Biotechnology and Biochemistry Volume: 未定
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] ビート食物繊維はラットの体脂肪を低下させ、視床下部レプチンレセプター遺伝子発現を増加させる (2012)
  • Author(s): 岸田太郎、水重貴文、瀬島浩一、海老原清
  • Journal Title: ルミナコイド研究 Volume: 16 Pages: 89-94
  • NAID: 40019568727
  • Peer Reviewed
• [Presentation] The elucidation of the mechanism of female specific food intake decrease in daidzein fed rats in meal feeding (2015)
  • Author(s): Tomoaki Izumi, Taro Kishida
  • Organizer: ACN2015
  • Place of Presentation: 横浜市
  • Year and Date: 2015-05-14 – 2015-05-18
• [Presentation] 3食制におけるダイゼインの食欲抑制効果の機構解明 (2014)
  • Author(s): 泉智明、岸田太郎
  • Organizer: 日本栄養食料学会中国・四国支部会
  • Place of Presentation: 徳島市
  • Year and Date: 2014-11-15
• [Presentation] 大豆イソフラボン腸内細菌代謝物エコールの飼料摂取量低下効果への腸肝循環の関与 (2013)
  • Author(s): 岸田太郎，藤谷美菜，水重貴文，山内佳也，村上 聖，山内 聡，海老原清
  • Organizer: 日本農芸化学会2013年度大会
  • Place of Presentation: 仙台
• [Presentation] ダイゼインの雌ラット特異的飼料摂取量低下はCCK-1 レセプターの欠損により消失しない (2012)
  • Author(s): 村上 聖、山内 佳也、本永 芳恵、梶原 秀平、山内 聡、 岸田 太郎、海老原 清
  • Organizer: 第67回日本栄養食糧学会大会
  • Place of Presentation: 仙台
• [Presentation] 摂食調節と肥満抑制
  • Author(s): 岸田 太郎
  • Organizer: 日本食物繊維学会
  • Place of Presentation: 福井県越前市塵埃大学
  • Invited