Appetite decreasing effect of soy isoflavone by novel mechanism via intestine
| Project/Area Number |
24580189
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Ehime University |
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Principal Investigator |
KISHIDA Taro 愛媛大学, 農学部, 教授 (80304658)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 食物繊維 / 摂取エネルギー / レプチン / 視床下部 / ラット / イソフラボン / 大豆 / 食欲 / エストロゲン / 神経伝達物質 |
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| Outline of Final Research Achievements |
Equol concentration in bile was higer than serum. The injected bile collected from rats fed daidzein significantly decreased food intake 12h after injection. After injection, the intestinal gene expression of CCK significantly increased and insignificant trend was observed in the gene expression of preproglucagon and peptide YY. Contrary to theresult in (2), we found that dietary equol decreased food intake regardress of CCKreceptor deficiency. CCK might not be a contributing factor in the mechanism of equol on decreased food intake in female rats.
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Report
(4 results)
Research Products
(8 results)
