Finding novel structured-lipids and prevention of life-style related diseases.
| Project/Area Number |
24580191
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Nishikyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAGAO Koji 佐賀大学, 農学部, 教授 (10336109)
YOTSUMOTO Hiroaki 西九州大学, 健康栄養学部, 准教授 (50321310)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 脂質構造異性体 / 高脂血症 / 脂肪肝 / 糖尿病 / 構造脂質 / 機能性脂質 / 脂質代謝 / 炎症 / 食品成分 / メタボ予防 / 新規機能性脂質 / オゾニド化脂質 / 海藻由来複合脂質 / 肥満動物 |
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| Outline of Final Research Achievements |
The concept of a “structured-lipid” implies modification of the fatty acid composition and/or their location in the glycerol backbone, and improvement of the physical and/or physiological properties of dietary lipids. Our study demonstrated that bioactive lipids (such as ozonized-olive oil and highly-unsaturated long chain fatty acids) or structured lipids (such as n-3 structured lipids, and phospholipids) displays at least two different physiological actions that alleviate obesity-induced diseases: one through the reduction of inflammatory damage by the regulation of in productions of adipocytekines and the other through the regulation of hepatic lipid synthesis. Thus, possible findings on the effects of the form, such as PL, TAG or DAG, used for the administration of bioactive fatty acids, such as ozonated-FAs and n-3 PUFAs, would be of great interest for future study.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] A comparison of the lipid-lowering effects of four different n-3 highly unsaturated fatty acids in HepG2 cells.2015
Author(s)
K. Yoshinaga, K. Sasaki, H. Watanabe, K. Nagao, N. Inoue, B. Shirouchi, T. Yanagita, T. Nagai, H. Mizobe, K. Kojima, F. Beppu, N. Gotoh
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Journal Title
J. Nutr. Biochem.
Volume: 26
Issue: 1
Pages: 57-63
DOI
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] 食事脂質とアディポネクチン2014
Author(s)
永尾晃治
Organizer
第68回日本栄養・食糧学会大会シンポジウム
Place of Presentation
酪農学園大学（北海道江別市）
Year and Date
2014-06-01
Related Report
Invited
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