| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
We established human embryonic kidney cells stably having human TRPM8, TRPV3, and TRPV4 genes, respectively. Then we searched for agonists or antagonists of TRPM8, TRPV3, and TRPV4 by the use of 30 kinds of essential oils or extracts from spices and herbs and found some active fractions for TRPM8 agonists and TRPV3 and TRPV4 antagonists. Further, we found novel TRPV1 and TRPA1 agonists from some spices and herbs. In addition we clarified effects of voacangine on thremo TRPs in detail. Also, effects of TRPM8 and TRPA1 agonists on visceral fats of high-fat and high-sucrose diets were performed and found that a TRPA1 agonist can reduce visceral fat deposition. Moreover, we established experiment system monitoring skin temperature of mice under awaking conditions by using infrared thermography.
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