| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Although a single substance, lactoferrin is known as being extremely multi-functional. We investigated the possibility that, besides the multi-functionality derived from the lactoferrin itself, lactoferrin expressed behaviors in conjunction with other bioactive components. Impurities in lactoferrin used as a reagent and food ingredient were fractionated using multi-stage methods, including affinity chromatography and ion exchange chromatography. The proteins and peptides present were examined using MALDI-TOF-MS proteomic analysis. Several components that exhibit bioactive characteristics, including immunomodulating effects and osteoblast proliferation were present among the impurities.
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