| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
We investigated the mechanisms that the irradiation of ultraviolet B (UVB), which is a major environmental factor that affects the structure and function of the skin, decreases the blood adiponectin level and plasminogen activator inhibitor (PAI)-1. Our results showed that the exposure of skin to UVB decreased the blood protein and adipose mRNA levels of adiponectin through the endocrine action of serum amyloid A increased by the activation of calcitonin gene-related peptide (CGRP) signals possibly via the skin-brain-liver axis. Furthermore, CGRP inhibited TGF-β1-induced expression of PAI-1 by decreasing the phosphorylation status of the MAP kinase pathway through activating the cAMP/protein kinase A pathway. UVB signals have both negative and positive effects such as a decline of skin function and alleviation of hepatic fibrosis, respectively. Therefore, our study would contribute to the elucidation of mechanisms underlying the endocrine and neuroendocrine functions of skin.
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