The effects of UVB irradiation to the skin on metabolic syndrome
| Project/Area Number |
24580199
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Tokyo University of Agriculture |
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Principal Investigator |
OISHI Yuichi 東京農業大学, 応用生物科学部, 教授 (00313073)
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| Research Collaborator |
MATUSI Sho
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 紫外線 / 皮膚 / CGRP / TGF-β1 / 急性期タンパク質 / インターロイキン-6 / アディポネクチン / PAI-1 / メタボリックシンドローム / マイクロアレイ |
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| Outline of Final Research Achievements |
We investigated the mechanisms that the irradiation of ultraviolet B (UVB), which is a major environmental factor that affects the structure and function of the skin, decreases the blood adiponectin level and plasminogen activator inhibitor (PAI)-1. Our results showed that the exposure of skin to UVB decreased the blood protein and adipose mRNA levels of adiponectin through the endocrine action of serum amyloid A increased by the activation of calcitonin gene-related peptide (CGRP) signals possibly via the skin-brain-liver axis. Furthermore, CGRP inhibited TGF-β1-induced expression of PAI-1 by decreasing the phosphorylation status of the MAP kinase pathway through activating the cAMP/protein kinase A pathway. UVB signals have both negative and positive effects such as a decline of skin function and alleviation of hepatic fibrosis, respectively. Therefore, our study would contribute to the elucidation of mechanisms underlying the endocrine and neuroendocrine functions of skin.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Hydrocellular foam dressings promote wound healing associated with decrease in inflammation in rat periwound skin and granulation tissue, compared with hydrocolloid dressings.2015
Author(s)
Yamane T, Nakagami G, Yoshino S, Shimura M, Kitamura A, Kobayashi-Hattori K, Oishi Y, Nishijima Y, Minematsu T, Sanada H.
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Journal Title
Biosci Biotechnol Biochem.
Volume: 79
Issue: 2
Pages: 185-189
DOI
Related Report
Peer Reviewed
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