Study of the functional molecules of the intestinal immune system for the inductive or regulative responses in the colon
| Project/Area Number |
24580200
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Nihon University |
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Principal Investigator |
HOSONO Akira 日本大学, 生物資源科学部, 教授 (70328706)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Kyoko 日本大学, 生物資源科学部, 准教授 (70366574)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 腸内細菌 / 大腸 / 免疫 / 小腸 / 免疫制御 / 食品機能 |
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| Outline of Final Research Achievements |
Although there are huge numbers of the commensal bacteria in the large intestine compared with the small intestine, the regulatory immune system, which was controlled for the prevention of the sensitive inflammatory reaction in the large intestine, was not understood. In this study, we have investigated to clarify the characteristics of the immune system in the large intestine. We have clarified that there are fewer expression of CD3 and activated CD4 T cells in the colonic patch cells compared with those in Peyer’s patch cells. In the germ-free mice, the frequency of these phenotypes was observed to be fewer than those in conventional mice. We have demonstrated that the frequency of the activated CD4 T cells were down-regulated in the large intestine than that in the small intestine.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] IgA production in the large intestine is modulated by a different mechanism than in the small intestine: Bacteroides acidifaciens promotes IgA production in the large intestine by inducing germinal center formation and increasing the number of IgA+ B cells.2013
Author(s)
Tsutomu Yanagibashia, Akira Hosono, Akihito Oyama, Masato Tsuda, Ami Suzuki, Satoshi Hachimura, Yoshimasa Takahashi, Yoshika Momose, Kikuji Itoh, Kazuhiro Hirayama, Kyoko Takahashi, Shuichi Kaminogawa
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Journal Title
Immunobiology
Volume: 218
Issue: 4
Pages: 645-651
DOI
Related Report
Peer Reviewed
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[Patent(Industrial Property Rights)] IgA分泌促進剤2013
Inventor(s)
宮里祥子，岸本由香，細野朗，高橋恭子，上野川修一
Industrial Property Rights Holder
松谷化学工業株式会社，学校法人日本大学
Industrial Property Rights Type
特許
Industrial Property Number
2013-021411
Filing Date
2013-02-06
Related Report
