| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
Although there are huge numbers of the commensal bacteria in the large intestine compared with the small intestine, the regulatory immune system, which was controlled for the prevention of the sensitive inflammatory reaction in the large intestine, was not understood. In this study, we have investigated to clarify the characteristics of the immune system in the large intestine. We have clarified that there are fewer expression of CD3 and activated CD4 T cells in the colonic patch cells compared with those in Peyer’s patch cells. In the germ-free mice, the frequency of these phenotypes was observed to be fewer than those in conventional mice. We have demonstrated that the frequency of the activated CD4 T cells were down-regulated in the large intestine than that in the small intestine.
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