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Creation of next-generation functional food by garlic-flavor precursor and polysaccharide/protein complex

Research Project

Project/Area Number 24580201
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Food science
Research InstitutionNihon University

Principal Investigator

KUMAGAI Hitomi  日本大学, 生物資源科学部, 教授 (20225220)

Co-Investigator(Renkei-kenkyūsha) KUMAGAI Hitoshi  共立女子大学, 家政学部, 教授 (20215015)
TANIGOME Atsuko (HASEGAWA Atsuko)  日本大学, 生物資源科学部, 助教 (30586326)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsニンニク臭気前駆体 / 呈味増強効果 / 嚥下困難者用ゲル状食品 / 肝障害抑制作用 / アリルシステインスルフォキシド / こく味 / 電子レンジ加熱 / 嗜好性向上 / 血糖値上昇抑制 / α-アミラーゼ阻害 / 非拮抗阻害
Outline of Final Research Achievements

In order to produce functional food with favorable palatability, swallowing property, and physiological property, garlic extract rich in S-allyll-L-cysteine sulfoxide (ACSO), garlic-odor precursor, was prepared, and its gelling, sensory, and functional properties were evaluated. ACSO content was the highest in a sample heated by microwave for 20 seconds.The addition of garlic extract to agar or gelatin gel did not affect the rheological properties so much. Flavor sensations were enhanced with the addition of garlic extract to gels containing taste substances. Oral administration of garlic extract suppressed hepatic injury induced by carbon tetrachloride.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (31 results)

All 2015 2014 2013 2012

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 1 results) Presentation (24 results) (of which Invited: 7 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Prevention of Osteoporosis by Oral Administration of Phytate-Removed and Deamidated Soybean β-Conglycinin2015

    • Author(s)
      Makoto Akao, Ryosuke Abe, Noriko Sato, Atsuko Hasegawa-Tanigome, Hitoshi Kumagai, Hitomi Kumagai
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 16 Issue: 1 Pages: 2117-2129

    • DOI

      10.3390/ijms16012117

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparative Study of the Antioxidative Activity of Culinary Herbs and Spices, and Hepatoprotective Effects of Three Selected Lamiaceae Plants on Carbon Tetrachloride-Induced Oxidative Stress in Rats2015

    • Author(s)
      Hideki Masuda, So Hironaka, Yoko Matsui, Saori Hirooka, Mami Hirai, Yushi Hirata , Makoto Akao, Hitomi Kumagai
    • Journal Title

      Food Science and Technology Research

      Volume: 21

    • NAID

      130005098070

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] “えん下困難者用食品”の基準中のテクスチャー試験法(TPA)に関する考察2014

    • Author(s)
      秋間彩香,谷米(長谷川)温子,熊谷日登美,熊谷仁
    • Journal Title

      日本食品工学会誌

      Volume: 15 Pages: 15-24

    • NAID

      130005057010

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the Reduced Allergenicity of Deamidated Gliadin in a Mouse Model of Wheat-Gliadin Allergy Using an Antibody Prepared by a Peptide Containing Three Epitopes2014

    • Author(s)
      Abe, R.; Shimizu, S.; Yasuda, K.; Sugai, M.; Okada, Y.; Chiba, K.; Akao, M.; Kumagai, H.; Kumagai, H.
    • Journal Title

      J. Agric. Food. Chem.

      Volume: 62 Issue: 13 Pages: 2845-2852

    • DOI

      10.1021/jf4034078

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 生体物質相互作用解析装置を用いた大豆7Sグロブリンとカルボキシル基との相互作用の解析 ―カルボキシレートタイプ陽イオン交換樹脂を用いたタンパク質の脱アミド化の機構解明のために―2012

    • Author(s)
      伊地知南,清水詩織,中西良博,佐藤典子,池田真理子,中野一輝,赤尾真,熊谷仁,熊谷日登美
    • Journal Title

      日本食品工学会誌

      Volume: 13 Pages: 117-125

    • NAID

      130005078808

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] シイタケフレーバー成分レンチオニンによる第二相解毒酵素誘導作用2012

    • Author(s)
      片山倫陽,赤尾真,熊谷日登美
    • Journal Title

      Aroma Research

      Volume: 13 Pages: 374-378

    • NAID

      40019507906

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] ニンニク/ブナシメジ抽出物による四塩化炭素誘発肝障害抑制作用2014

    • Author(s)
      平田裕史,斉藤武,市村昌紀,赤尾真,熊谷日登美
    • Organizer
      第19回日本フードファクター学会学術集会
    • Place of Presentation
      鹿児島大学( 鹿児島)
    • Year and Date
      2014-11-08 – 2014-11-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] シイタケ抽出物による四塩化炭素誘発肝障害抑制効果2014

    • Author(s)
      平井眞実,荒井隆志,齋野安那,赤尾真,熊谷日登美
    • Organizer
      第19回日本フードファクター学会学術集会
    • Place of Presentation
      鹿児島大学( 鹿児島)
    • Year and Date
      2014-11-08 – 2014-11-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Prevention of hepatic injury by intake of garlic-flavor precursor together with ornithine2014

    • Author(s)
      Yushi Hirata, Takeshi Saito, Masaki Iichimura, Makoto Akao, Hitomi Kumagai
    • Organizer
      International Conference and Exhibition on Nutraceuticals and Functional Foods 2014 (ISNFF 2014)
    • Place of Presentation
      Istanbul, Turkey
    • Year and Date
      2014-10-14 – 2014-10-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] ゲル状食品へのニンニク抽出物添加によるコク味の変化2014

    • Author(s)
      谷米温子,中西良博,若林素子,赤尾真,熊谷仁,熊谷日登美
    • Organizer
      日本食品科学工学会第59回大会
    • Place of Presentation
      中村学園大学( 福岡)
    • Year and Date
      2014-08-28 – 2014-08-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 多糖類ゲルのテクスチャーと嚥下特性2014

    • Author(s)
      篠原由妃,秋間彩香,谷米温子 ,熊谷日登美,熊谷仁
    • Organizer
      日本食品科学工学会第59回大会
    • Place of Presentation
      中村学園大学( 福岡)
    • Year and Date
      2014-08-28 – 2014-08-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] えん下困難者用食品およびユニバーサルデザインフードの物性指標に関する研究2014

    • Author(s)
      山形文乃,秋間彩香,篠原由紀 ,谷米温子,熊谷日登美,熊谷仁
    • Organizer
      日本食品科学工学会第59回大会
    • Place of Presentation
      中村学園大学( 福岡)
    • Year and Date
      2014-08-28 – 2014-08-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] ニンニク臭気前駆体とアルギニン/オルニチンによる四塩化炭素誘発肝障害抑制作用2014

    • Author(s)
      平田裕史,斉藤武,市村昌紀,赤尾真,熊谷日登美
    • Organizer
      日本食品科学工学会第59回大会
    • Place of Presentation
      中村学園大学( 福岡)
    • Year and Date
      2014-08-28 – 2014-08-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 増粘剤溶液およびゲルの食塊の流動性と咽頭部における流速の関係2014

    • Author(s)
      秋間彩香,田代晃子,谷米(長谷川)温子,熊谷日登美,熊谷仁
    • Organizer
      日本食品工学会第15回(2014年度)年次大会
    • Place of Presentation
      つくば国際会議場( 茨城県つくば市)
    • Year and Date
      2014-08-07 – 2014-08-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] シイタケフレーバー成分レンチオニンによる血小板形態変化阻害機序2014

    • Author(s)
      平井眞美,金田誠也,鈴木ひかり,島田正一郎,赤尾真,熊谷日登美
    • Organizer
      第67回日本栄養・食糧学会大会
    • Place of Presentation
      名古屋大学( 名古屋)
    • Year and Date
      2014-05-24 – 2014-05-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Suppression of Postprandial Hyperglycemia by an Amino Acid in Allium Plant2014

    • Author(s)
      Makoto Akao, Yushi Hirata, Tomomi Kobayashi, Hitomi Kumagai
    • Organizer
      105th AOCS Annual Meeting & Expo
    • Place of Presentation
      Henry B. Gonzalez Convention Center,San Antonio, Texas, USA
    • Year and Date
      2014-05-04 – 2014-05-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Induction of Oral Tolerance by Deamidated Wheat Gliadin2014

    • Author(s)
      Hitomi Kumagai, Ryosuke Abe, Makoto Akao, Hitoshi Kumagai
    • Organizer
      105th AOCS Annual Meeting & Expo
    • Place of Presentation
      Henry B. Gonzalez Convention Center,San Antonio, Texas, USA
    • Year and Date
      2014-05-04 – 2014-05-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Achievements and Discoveries as to Functional Foods in Japan2014

    • Author(s)
      Hitomi Kumagai
    • Organizer
      Experimental Biology
    • Place of Presentation
      San Diego Convention Center, San Diego, CA, USA
    • Year and Date
      2014-04-26 – 2014-04-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Therapeutic function of deamidated gliadin in wheat allergy2013

    • Author(s)
      Hitomi Kumagai
    • Organizer
      104th AOCS Annual Meeting & Expo
    • Place of Presentation
      Palais des congrès de Montréal, Montréal, Québec, Canada
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Physiological functions of a flavor component from shiitake mushrooms2013

    • Author(s)
      Hitomi Kumagai, Makoto Akao
    • Organizer
      20th International Congress of Nutrition
    • Place of Presentation
      Granada, Spain
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Reduction in allergenicity of wheat gliadin by deamidation2013

    • Author(s)
      Hitomi Kumagai, Ryosuke Abe, Makoto Akao, Hitoshi Kumagai
    • Organizer
      International Conference and Exhibition on Nutraceuticals and Functional Foods 2013
    • Place of Presentation
      Howard Civil Service International House, Taipei, Taiwan
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] ニンニク臭気前駆体物質のα-アミラーゼ活性阻害作用2013

    • Author(s)
      赤尾真,小林ともみ,白井佑弥,宮田翔子,熊谷日登美
    • Organizer
      第67回日本栄養・食糧学会大会
    • Place of Presentation
      名古屋大学(名古屋)
    • Related Report
      2013 Research-status Report
  • [Presentation] TPA試験から求められるパラメータと多糖類ゲルの嚥下特性2013

    • Author(s)
      秋間彩香,篠原由妃,谷米(長谷川)温子,熊谷日登美,熊谷仁
    • Organizer
      日本食品工学会第14回(2013年度)年次大会
    • Place of Presentation
      京都テルサ(京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] ニンニク臭気前駆体物質によるα-アミラーゼ阻害活性2013

    • Author(s)
      平田 裕史,小林 ともみ,赤尾 真,袴田 航,熊谷 仁,熊谷 日登美
    • Organizer
      日本食品工学会第14回(2013年度)年次大会
    • Place of Presentation
      京都テルサ(京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] ゲル状食品の咀嚼物粘度と食塊の流速との関係2013

    • Author(s)
      篠原由妃,秋間彩香,谷米温子 ,熊谷日登美,熊谷仁
    • Organizer
      日本食品科学工学会第60回大会
    • Place of Presentation
      実践女子大学(東京)
    • Related Report
      2013 Research-status Report
  • [Presentation] ニンニクフレーバー前駆体物質の血中脂質上昇抑制作用2013

    • Author(s)
      平田裕史,北田杏和,赤尾真,熊谷日登美
    • Organizer
      日本食品科学工学会第60回大会
    • Place of Presentation
      実践女子大学(東京)
    • Related Report
      2013 Research-status Report
  • [Presentation] Bioactive Amino Acid that Prevents Hepatic Injury2012

    • Author(s)
      Hitomi Kumagai
    • Organizer
      103rd AOCS Annual Meeting & Expo
    • Place of Presentation
      Long Beach Convention Center、 Long Beach、 California、 USA
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Suppression of postprandial hyperglycemia by odor precursor of garlic2012

    • Author(s)
      Tomomi Kobayashi、 Yuya Shirai、 Shoko Miyata、 Makoto Akao、 Hitoshi Kumagai、 Hitomi Kumagai
    • Organizer
      The 6th International Niigata Symposium on Diet and Health
    • Place of Presentation
      Niigata Convention Center、 Toki Messe(新潟)
    • Related Report
      2012 Research-status Report
  • [Presentation] ニンニク臭気前駆体物質による食後血糖値上昇抑制作用2012

    • Author(s)
      小林ともみ、白井佑弥、 宮田翔子、赤尾真、熊谷日登美
    • Organizer
      第27回日本香辛料研究会
    • Place of Presentation
      日本大学生物資源科学部(藤沢)
    • Related Report
      2012 Research-status Report
  • [Presentation] ニンニクフレーバー前駆体の高濃度抽出とその嗜好性評価2012

    • Author(s)
      北田杏和、岩田麻美、 竹本晴香、皆川絵美、赤尾真、 熊谷日登美
    • Organizer
      日本農芸化学会関東支部2012年度大会
    • Place of Presentation
      新潟薬科大学(新潟)
    • Related Report
      2012 Research-status Report
  • [Patent(Industrial Property Rights)] α-アミラーゼ阻害剤2012

    • Inventor(s)
      熊谷日登美、 赤尾真、 小林ともみ
    • Industrial Property Rights Holder
      熊谷日登美、 赤尾真、 小林ともみ
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-194643
    • Filing Date
      2012-09-05
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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