| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Outline of Final Research Achievements |
ATM and ATR protein kinases play a crucial role in cellular DNA damage responses. The inhibition of these kinases and related molecules lead to an abolishment of one such signal pathways termed as ”checkpoints”. It is expected that the discovery of checkpoint modulator will be an effective assistance of anti-cancer therapy. We discovered several candidates from foods including resourses of traditional medicines. Gomisin-N and Persimmon leaf foavonols (PLF) inhibited ATR and ATM in vivo and in vitro, respectivly. The inhibitory effect of PLF was observed in xenograft mice which irradiated with heavy ion carbon beam. Addition, we discovered some food stuffs which inhibit tumor cell growth such as 3,4-dihydroxybenzalacetone, feruic acid/gamma-tocotorienol and phosphatidylcholine peroxide. Here, we revealed anti-cancer effects of ingrients of foods, and clarified detailed mechanisms of intracellular signal regulation.
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