Elucidation of the functionality of the phytoestrogen-metabolizing intestinal bacteria
| Project/Area Number |
24580206
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | National Agriculture and Food Research Organization |
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Principal Investigator |
TAMURA Motoi 独立行政法人農業・食品産業技術総合研究機構, 食品総合研究所食品機能研究領域, 上席研究員 (70353943)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Hiroyuki 独立行政法人農業・食品産業技術総合研究機構, 食品総合研究所・食品安全研究領域, 主任研究員 (30308192)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | フィトエストロゲン / エコール / ダイゼイン / 植物リグナン / エンテロジオール / マウス / 腸内菌叢 / 脂質代謝 / 腸内細菌 / セコイソラリシレジノール / エンテロラクトン / リグナン / エストロゲン |
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| Outline of Final Research Achievements |
Soy isoflavone and plant lignan are belong to the phytoestrogens. In this study, we found that the administration of equol-producing bacteria to the mice fed the diet containing daidzein and plant lignan increased the equol production as compared to the mice administrated physiological saline. Co-administration of three lignan-metabolizing bacteria and two isoflavone-metabolizing bacteria to the mice increased the enterodiol production as compared to the mice administrated physiological saline. Our results suggest that the administration of lignan-metabolizing bacteria to the mice fed the diet containing daidzein and plant lignan affects the lipid metabolism of mice differently from the administration of lignan-metabolizing bacteria plus isoflavone-metabolizing bacteria to the mice fed the diet containing daidzein and plant lignan.
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Report
(4 results)
Research Products
(7 results)
