| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Food poisoning caused by Kudoa septempunctata, a myxosporean infecting the muscle of olive flounder Paralichthys olivaceus, has been a problem in Japan. Recently, other Kudoa spp. has been also suspected to be aetiological agents of food poisoning in humans. Prevalence of infection with Kudoa iwatai was relatively high in yellowfin seabream Acanthopagrus latus, whereas maturity of cysts and viability of spores were high in Japanese seabass Lateolabrax japonicus. Toxicity of K. iwatai could not be demonstrated in Caco-2 cell monolayer permeability assay. On the other hand, toxicity of Kudoa hexapunctata, a newly described species from juvenile Pacific bluefin tuna Thunnus orientalis, to Caco-2 cells were shown. Risk assessment of K. hexapunctata was made based on some information of spore dose with toxic effects on Caco-2 cells and treatment conditions inactivating the spores.
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