| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Seafoods, including fish, crustaceans and mollusks, are well recognized as one of the most common causes of food allergy mediated by immunoglobulin E antibodies. However, the mechanism concerning to onset of seafood allergy is not elucidated, and the details of the gene expression in conjunction with the onset are not clarified.
Therefore, in this study, seafood allergy model mouse was constructed for the purpose of the identification of the gene cluster about onset of seafood allergy. As a result, the gene which the expression increased was specifically identified in case of the onset of seafood allergy by the cDNA subtraction method. It was revealed that a kind of cytokine called interleukin-5 specifically participated in the onset of seafood allergy.
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